Formation and function of SHAP-hyaluronan complex as a niche molecule in inflammatory microenvironment

2014 Fiscal Year Final Research Report

• Project/Area Number: 23570148
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Structural biochemistry
• Research Institution: Aichi Medical University
• Principal Investigator: KIMATA Koji 愛知医科大学, その他部局等, 名誉教授 (10022641)
• Co-Investigator(Kenkyū-buntansha): ZHUO Lisheng 愛知医科大学, 公私立大学の部局等, その他 (00399031)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 炎症 / 酵素 / 細胞接着 / ヒアルロン酸 / 血清タンパク質

Outline of Final Research Achievements

Serum-derived hyaluronan (HA)-associated proteins (SHAP) binds covalently to HA, which plays important roles in inflammation and tumor malignance, to assign it novel physiological functions. This project aims to isolate the enzymatic factor calalyzing the formation of the SHAP-HA complex and screen its inhibitor. In addition, the roles of the SHAP-HA complex as a member of inflammatory niche in mouse models of acute liver failure, functional regeneration of muscle after injury by mesenchymal stem cell transplantation, and chronic painful scar are investigated.

Free Research Field

細胞外マトッリクス、プロテオグリカン