2013 Fiscal Year Final Research Report
Regulation of cell morphology by tricellular junction in epithelia
| Project/Area Number |
23570229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kobe University |
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Principal Investigator |
YUKAKO Oda 神戸大学, 医学(系)研究科(研究院), 助教 (70452498)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 細胞間接着 / 細胞形態 |
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| Research Abstract |
When the surface view of each epithelial cell is compared with a polygon, its sides correspond to cell–cell junctions, while its vertices correspond to tricellular contacts, whose roles in epithelial cell morphogenesis have not been well studied. We have shown that tricellulin, which is localized at tricellular contacts, regulates F-actin organization via Cdc42 and Tuba; a Cdc42 GEF. These findings indicate that tricellular contacts play crucial roles in regulating the actomyosin-mediated apical junctional complex tension through the tricellulin-Tuba-Cdc42 system.
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