Analysis of regulatory mechanisms of newly identified ERK substrates

2014 Fiscal Year Final Research Report

• Project/Area Number: 23570231
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: The University of Tokushima
• Principal Investigator: KOSAKO Hidetaka 徳島大学, 藤井節郎記念医科学センター, 教授 (10291171)
• Co-Investigator(Renkei-kenkyūsha): SAITOH Hisato 熊本大学, 大学院自然科学研究科, 教授 (50211925) ; TSUMOTO Kouhei 東京大学, 大学院工学系研究科, 教授 (90271866)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: ERK / MAPキナーゼ / リン酸化 / 細胞内情報伝達 / 細胞運動 / 抗リン酸化抗体 / プロテオーム

Outline of Final Research Achievements

ERK/MAP kinase is evolutionally conserved in eukaryotes and plays multiple and important roles in cells by phosphorylating various substrates. We have recently identified new ERK substrates by developing a phosphoproteomic approach. In this study, we identified phosphorylation sites of several of these ERK substrates and biochemically analyzed phosphorylation-dependent regulation of their functions. Furthermore, each ERK substrate was shown to be involved in ERK-mediated regulation of cellular functions.

Free Research Field

生物学