2013 Fiscal Year Final Research Report

Nonalcoholic steatohepatitis induced by the excess ingestion of fructose and its prevention by functional foods ingredient

Research Project

Project/Area Number	23580181
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Food science
Research Institution	Osaka Prefecture University
Principal Investigator	INUI Hiroshi 大阪府立大学, 総合リハビリテーション学部, 教授 (20193568)
Project Period (FY)	2011 – 2013
Keywords	スクロース / フルクトース / 腸管吸収 / 腸内細菌叢 / 脂肪性肝炎 / 肥満 / 機能性食品成分 / NASH
Research Abstract	When KK-Ay mice were fed a high-sucrose or high-fructose diet, the growth of Bifidobacterium in cecum was suppressed. The change in microflora may associate with the pathology of nonalcoholic steatohepatitis induced by the excess ingestion of fructose, as well as the case of the ingestion of high-fat diets. From eucalyptus extract, tellimagrandin I, a kind of ellagitannins, was isolated as an inhibitor for intestinal fructose absoption. In addition to eucalyptus extract, banaba, guava and olive extracts also inhibited intestinal fructose absorption and suppressed adiposity induced by the excess ingestion of fructose in rats.