2013 Fiscal Year Final Research Report
Development and application of the environmental friendly and highly efficient organic synthesis using characteristics of the heterocycle
| Project/Area Number |
23590031
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
KAWASAKI Ikuo 武庫川女子大学, 薬学部, 教授 (00234055)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIDE Kiyoharu 武庫川女子大学, 薬学部, 教授 (10237711)
YAMASHITA Yamashita 京都薬科大学, 薬学部, 教授 (20239982)
UCHIMOTO Hitomi 武庫川女子大学, 薬学部, 助手 (23590031)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 複素環 / イオン化合物 / キラルリガンド / 不斉合成 / 環境調和型 |
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| Research Abstract |
Various novel chiral ionic ligands which has the structure of the quaternary ammonium salt in the nitrogen containing heterocycle were prepared. There catalytic ability was evaluated by asymmetric reduction of prochiral ketones in the catalytic asymmetric transfer hydrogenation (CATH) by using chiral ionic ligands, Ru and formic acid as a hydrogen source and ionic liquid as a reaction medium. Furthermore, this reaction system of CATH could be expanded to recycling CATH (RCATH). From these results, I could achieve the development of the environmental friendly and highly efficient organic synthesis using characteristics of the heterocycle. And this method could be applied to the asymmetric synthesis of pharmaceutical useful compound.
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[Journal Article] Preparation of benzo[b]furans having five- membered heterocycles at the 2-position and 2-(4-alkylcarbamoylbuta-1,3-dienyl)benzo[b]f urans, and their cysteinyl leukotriene receptor (cysLT1, cysLT2) inhibitory activity2012
Author(s)
Yukiko Akai, Y. Tabuchi, K. Ando, A. Ito, Y. Sakata, I. Kawasaki, T. Ohishi, M. Yamashita, S. Ohta, Nishide, Y. Ohishi
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Journal Title
Chem. Pharm. Bull
Volume: 60 (11)
Pages: 1461-1467
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[Journal Article] Synthesis of (±)-8-deisopropyladunctin B2012
Author(s)
S. Nomura, K. Arimitsu, S. Yamaguchi, Y. Kosuga, Y. Kakimoto, T. Komai, K. Hasegawa, Nakanishi, T. Miyoshi, H. Iwasaki, M. Ozeki, I. Kawasaki, A. Kurume, S., M. Yamashita
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Journal Title
Chem. Pharm. Bull
Volume: 60 (1)
Pages: 94-103
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