2013 Fiscal Year Final Research Report
Development of multi-point recognizing derivatization procedures for reliable diagnoses of inborn errors of metabolism
| Project/Area Number |
23590046
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | Tokyo University of Science |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 分析科学 / 先天性代謝異常症 / LC/ESI-MS/MS / 多点分子認識 / 誘導体化 / 精密検査 / バイオマーカー / 高感度 |
|---|
| Research Abstract |
The multi-point recognizing derivatization procedures, which enable to the highly sensitive and specific determination of diagnostic makers by LC/ESI-MS/MS, have been developed for reliable diagnoses of inborn errors of metabolism, such as congenital adrenal hyperplasia (CAH). The developed procedures was applied to the clinical sample analyses (dried blood spot, urine, saliva and so on) and proved to have sufficient practicality in diagnoses of CAH, long-chain 3-hydroxyacyl CoA dehydrogenase deficiency and neonatal vitamin D deficiency.
|
Research Products
(14 results)
