2014 Fiscal Year Final Research Report
Study on a role of NMDA receptor in chemical-induced hepatotoxicity
| Project/Area Number |
23590150
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | NMDA受容体 / 肝臓 / 肝肥大 / 環境化学物質 / 肝がん細胞 / 肝毒性 / 肝細胞障害 / 肝発がん |
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| Outline of Final Research Achievements |
The present studies demonstrated that the treatments with chemicals inducing hepatocellular hypertrophy, hepatocyte injury, and/or liver hypertrophy resulted in super-induction of NMDA receptor 2C subunit gene (Grin 2c) expression in the rat livers, suggesting that NMDA receptor plays an important role in chemical-induced hepatotoxicity. However, induced Grin2c gene expression could not be found in chemical-treated hepatic cell lines. The induction of Grin2c gene expression might result from certain cellular factors produced from different types of hepatic cells from parenchymal hepatocytes.
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| Free Research Field |
分子毒性学
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