2013 Fiscal Year Final Research Report
Role of associative fiber tracts on sulcal development of the cerebrum in ferrets
| Project/Area Number |
23590223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tsukuba International University |
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Principal Investigator |
SAWADA Kazuhiko つくば国際大学, 保健医療学部, 教授 (10284324)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 大脳 / 進化 / 系統発生 / MRI / フェレット / volumetry / 脳溝 / 脳回 |
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| Research Abstract |
Male and female ferrets at postnatal days (PDs) 4 to 90 were perfused with 4% paraformaldehyde solution, and the brains were removed. The chronology of sulcal and gyral emergences were clarified using those brain samples by gross anatomic observations. T1W-MRI was further acquired from the fixed brain using a high spatial resolution 7-tesla MRI. T1W-MRI-based maximum intensity projection (MIP) could delineate functional cortical areas related to myeloarchitecure in 3D. Quantitative analysis of the sulcal infolding revealed a male-prominent posterior extension of neocortical and archicortical sulci with cortical expansion in the temporo-parieto-occipital region of the cerebrum. Fractional anisotropy was measured in the subcortical white matter of the sulcal and gyral regions of the ferret cerebra using diffusion tensor imaging (DTI). However, it was unclear a relation of sulcal development with the development of subcortical white matter bundles.
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