2013 Fiscal Year Final Research Report
Shared mechanisms of the transcription factor IRF8 and the cAMP pathway in macrophage differentiation
| Project/Area Number |
23590343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
NISHIYAMA Akira 横浜市立大学, 医学(系)研究科(研究院), 准教授 (80589664)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Tomohiko 横浜市立大学, 医学研究科, 教授 (50285144)
ICHINO Motohide 横浜市立大学, 医学部, 助教 (60271368)
HOTTA Chie 横浜市立大学, 医学部, 助教 (80363810)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 細胞内シグナル伝達 / 血球分化 / 転写因子 |
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| Research Abstract |
Cell differentiation requires appropriate changes in gene expression patterns, which are tightly regulated by cell type-specific transcription factors. Dysregulation of these processes can result in disorders incuding leukemias. IRF8 is a hematopoietic transcription factor that regulates the development of multiple immune cell types, and also it is considered as an important regulatory factor for chronic myelogenous leukemia. In this study, we have investigated the differentiation program of myeloid cells by functional analyses of IRF8 with the aim of the future clinical application for chronic myelogenous leukemia. We performed gene expression profiling of macrophage differentiation induced by multiple procedures including IRF8 ectopic expression. We found the common transcription factors in macrophage differentiation induced by multiple procedures. Indeed, the ectopic expression of these transcription factors induced macrophage differentiation without IRF8 expression.
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