2013 Fiscal Year Final Research Report
Proteomic analysis of arterial aging and medial degenerative diseases (aortic dissection, cerebral aneurysm and cerebral arterial dissection)
| Project/Area Number |
23590422
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical and Dental University (2012-2013)
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2011) |
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Principal Investigator |
SAWABE Motoji 東京医科歯科大学, 保健衛生学研究科, 教授 (30196331)
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| Co-Investigator(Kenkyū-buntansha) |
RHO Ayako 東京女子医科大学, 講師 (50296555)
TODA Toshifusa 東京都健康長寿医療センター研究所, 研究 副部長 (80133635)
MIURA Yuri 東京都健康長寿医療センター研究所, 研究 副部長 (00216574)
TANAKA Hiroshi 東京医科歯科大学, 難治疾患研究所, 教授 (60155158)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 循環器 / プロテオーム / 老化 / 動脈老化 / 大動脈解離症 |
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| Research Abstract |
The aging-related arterial medial change (arterial aging) causes heart failure and chronic kidney disease in the elderly. Aortic dissection may arise from some unidentified anomaly of the aortic media. The purpose of this study is to analyze the changes of arterial medial constitutive proteins in arterial aging and aortic dissection using the comprehensive proteome analysis. In the cases of aortic dissection, there were increase and decrease of smooth muscle contraction proteins, increase of stress response proteins, and decrease of extracellular matrix proteins. Arterial aging was associated with decrease of smooth muscle actin, increase of stress response proteins, and increase of proteins of extracellular glycosaminoglycans. We successfully identified the specific changes of arterial medial constitutive proteins seen in arterial aging and aortic dissection.
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[Presentation] ヒト大動脈解離症のプロテオーム解析2014
Author(s)
三浦ゆり, 岩本真知子, 津元裕樹, 副島友莉恵, 戸田年総, 森澤拓, 新井冨生, 濱松晶彦, 遠藤玉夫, 沢辺元司
Organizer
日本プロテオーム学会2014年会
Place of Presentation
つくば
Year and Date
20140717-18
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[Presentation] Proteomic analysis of the human aortic media2013
Author(s)
Sawabe, M., Yoshida, S., Hamamatsu, A., Toda, T., Arai, T., Iwamoto, M., Endo, T., Miura, Y.
Organizer
8th Asia Pacific IAP Congress (APIAP)
Place of Presentation
Busan, Korea
Year and Date
20130905-08
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[Presentation] Proteomic analysis of the elastic arterial media in aging2013
Author(s)
Sawabe, M., Yoshida, S., Hamamatsu, A., Toda, T., Arai, T., Iwamoto, M., Endo, T., Miura, Y.
Organizer
81st European Atherosclerosis Society (EAS) Congress
Place of Presentation
Lyon, France
Year and Date
20130602-05
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