2013 Fiscal Year Final Research Report
Role and possibility as a therapeutic target of aPKClambda/iota in intractable cancers
| Project/Area Number |
23590429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Yokohama City University |
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Principal Investigator |
NAGASHIMA Yoji 横浜市立大学, 医学(系)研究科(研究院), 准教授 (10217995)
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| Co-Investigator(Kenkyū-buntansha) |
AKIMOTO Kazunori 東京理科大学, 薬学部, 准教授 (70285104)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIGURO Hitoshi 横浜市立大学, 医学研究科, 客員准教授 (00381666)
AOKI Ichiro 横浜市立大学, 医学研究科, 教授 (00184028)
INAYAMA Yoshiaki 横浜市立大学, 市民総合医療センター, 教授 (10184730)
UEMURA Hiroji 横浜市立大学, 附属病院, 准教授 (50244439)
SATO Mikiko 横浜市立大学, 附属病院, 講師 (70326049)
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| Research Collaborator |
TANIGUCHI Tamiyo 横浜市立大学, 医学部, 技術吏員
MIZUSHIMA Taichi 横浜市立大学, 大学院生
IZUMISAWA Yusuke 横浜市立大学, 大学院生
KATO Shingo 横浜市立大学, 大学院生
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| Project Period (FY) |
2011 – 2013
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| Keywords | 細胞極性 / aPKC / IL6 / 癌細胞 / 免疫組織化学 |
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| Research Abstract |
Abnormality of cell polarity is one of the principal features of cancer cells. We immunohistochemically examined the expression and localization of atypical protein kinaselamda/iota (aPKC), a pivotal reguilator of cell polarity, in various cancer tissues. Additionally, we have examined the correlationship between aPKC and interleukin 6 (IL6), a downstream molecule of aPKC in prostatic cancer specimens.
Immunohistochemically, increased expression of aPKC was demonstrated in gastric cancer, malignant melanoma, pancreatic cancer, oral cancer and uterine cervical cancer, in concordance with metastasis and profgression from precancerous state. Additionally, increased coexpression with IL6 was demonstrated in the clinical specmens of prostatic cancer.
Thus, we found that aPKC and IL6 would be a feasible therapeutic targets of intractable cancers.
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[Presentation] The nuclear localization and overexpression of atypical protein kinase C in cervical cancer correlate with prognosis2012
Author(s)
水島大一, 秋本和憲, 長嶋洋治, 最上多恵, 佐藤美紀子, 宮城悦子, 亀田陽一, 稲山嘉明, 大橋健一, 青木一郎, 大野茂男, 平原史樹
Organizer
第71回日本癌学会学術総会
Place of Presentation
北海道,札幌市,ロイトン札幌
Year and Date
2012-09-19
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[Presentation] aPKCλ/ιregulates mammary luminal progenitor cell propagation and its disruption in a subpopulation of breast cancer2011
Author(s)
秋本和憲, 長嶋洋治, 石黒斉, 鄭允文, 佐々木和教, 小島康幸, 谷口英樹, 大野茂男, 野田哲生
Organizer
第70回日本癌学会学術集会
Place of Presentation
愛知県,名古屋市,名古屋国際会議場
Year and Date
2011-10-03
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