2013 Fiscal Year Final Research Report
Identification and the elucidation of the mechanism of interleukin 18 induced metastasis inhibitory factor(s)
| Project/Area Number |
23590480
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
YAMADA Naoko 兵庫医科大学, 医学部, 講師 (10319858)
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| Co-Investigator(Kenkyū-buntansha) |
TERADA Nobuyuki 兵庫医科大学, 医学部, 名誉教授 (50150339)
NAKASHO Keiji 兵庫医科大学, 医学部, 教授 (00217712)
OHYAMA Hideki 兵庫医科大学, 医学部, 准教授 (90280685)
YAMANEGI Koji 兵庫医科大学, 医学部, 講師 (00434944)
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| Project Period (FY) |
2011 – 2013
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| Keywords | インターロイキン18 / 転移 / 骨肉腫 |
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| Research Abstract |
We showed the possibility of the presence of IL-18-induced metastasis inhibitory factor(s) in the previous paper. The purpose of this research is to identify the factor(s) and to clarify its metastasis suppression mechanism. We revealed that this factor mainly existed in serum. We found 32 candidates of the factor(s) using the antibody arrays. As a result of investigating the metastasis suppressing activity of five factors with high expression level, three of them inhibited the tumor cell invasion. Further, we found 42 candidates of the factor(s) through two-dimensional electrophoresis and the MALDI-TOF-MS.
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Research Products
(12 results)
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[Journal Article] Decreased expression of VE-cadherin and claudin-5 and increased phosphorylation of VE-cadherin in vascular endothelium in nasal polyps2013
Author(s)
Yukitatsu Y, Hata M, Yamanegi K, Yamada N, Ohyama H, Nakasho K, Kojima Y, Oka H, Tsuzuki K, Sakagami M, Terada N
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Journal Title
Cell Tissue Res
Volume: 352(3)
Pages: 647-57
DOI
Peer Reviewed
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[Journal Article] Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells2012
Author(s)
Yamanegi K, Yamane J, Kobayashi K, Ohyama H, Nakasho K, Yamada N, Hata M, Fukunaga S, Futani H, Okamura H, Terada N
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Journal Title
Oncol Rep
Volume: 28(5)
Pages: 1585-90
DOI
Peer Reviewed
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[Journal Article] Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fas- and NK cell-mediated cell death2012
Author(s)
Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, Yamada N, Hata M, Fukunaga S, Futani H, Okamura H, Terada N
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Journal Title
Int J Oncol
Volume: 41(1)
Pages: 83-91
DOI
Peer Reviewed
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[Journal Article] The promotional effect of IL-22 on mineralization activity of periodontal ligament cells2012
Author(s)
Kato-Kogoe N, Nishioka T, Kawabe M, Kataoka F, Yamanegi K, Yamada N, Hata M, Yamamoto T, Nakasho K, Urade M, Terada N, Ohyama H
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Journal Title
Cytokine
Volume: 59(1)
Pages: 41-8
DOI
Peer Reviewed
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