2013 Fiscal Year Final Research Report
The elucidation of the acquisition of resistance mechanism in multidrug-resistant Pseudomonas aeruginosa and application to simple diagnosis system and infection control
| Project/Area Number |
23590691
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokai University |
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Principal Investigator |
ASAI Satomi 東海大学, 医学部, 講師 (60365989)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYACHI Hayato 東海大学, 医学部, 教授 (20174196)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 緑膿菌 / アシネトバクター / 多剤耐性 / 耐性獲得機構 / 迅速検査 / 感染制御 |
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| Research Abstract |
The antimicrobial resistance and the expression of the drug resistance related genes were investigated using clinical isolates of drug resistant Pseudomonas aeruginosa for the development of the examination for simple and quick diagnosis system. Using the clinical isolated P. aeruginosa which had co-expression of MexEF-OprN and MexXY-OprM, the development of the diagnosis systems for the detection of the resistance gene by observing presence of each gene expression visually and Enzyme-linked immunosorbent assay (the ELISA method) were tried.
The contribution of the drug effluxing pump was not strong in Acinetobacter baumannii, and contribution of other gene expression was considered.
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Research Products
(51 results)
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[Journal Article] 造血幹細胞移植患者における内因性細菌叢監視培養検査の臨床的意義2013
Author(s)
大島利夫, 浅井さとみ, 大菅淳, 山本由香梨, 野宮沙織, 矢部みはる, 矢部普正, 加藤俊一, 鬼塚真仁, 安藤潔, 大崎敬子, 神谷茂, 宮地勇人
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Journal Title
J Germfree Life Gnotobiol
Volume: 43
Pages: 91-96
Peer Reviewed
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