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2013 Fiscal Year Final Research Report

The effects of maternal exposure of persistent organochlorine pesticides on allergic and infection's symptoms in infancy

Research Project

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Project/Area Number 23590769
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Public health/Health science
Research InstitutionHokkaido University (2012-2013)
Junior College, Asahikawa University (2011)

Principal Investigator

KANAZAWA Ayako  北海道大学, 環境健康科学研究教育センター, 客員研究員 (90201425)

Co-Investigator(Kenkyū-buntansha) HANDA Yasushi  北海道大学, 遺伝子病制御研究所, 客員研究員 (70571785)
MIYASHITA Chihiro  北海道大学, 環境健康科学研究教育センター, 特任助教 (70632389)
Project Period (FY) 2011 – 2013
Keywords母子保健 / ヒト次世代影響 / 難分解性有機塩素系農薬 / 喘息 / アトピー / 感染症
Research Abstract

Previous studies suggest that persistent organochlorine (POC) pesticides may contribute to endocrine disruption. The purpose of this study was to investigate the association between POCs levels in maternal blood and the risk of allergies in infancy. Between 2002 and 2005, 514 pregnant women were recruited in Sapporo Toho Hospital, and 29 POC pesticides in 320 whole blood samples were measured. No associations between POC pesticides levels and allergic symptoms at 18 month of age were observed in adjusted logistic regression analysis. At background levels, prenatal exposure to POC pesticides may alter immune function during childhood. Therefore, more long-term observations are needed to assess whether developmental exposure may result in allergic diseases in later childhood.

  • Research Products

    (13 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (3 results) Remarks (2 results)

  • [Journal Article] Association of Mechanical Ventilation and Flue Use in Heaters With Asthma Symptoms in Japanese Schoolchildren : A Cross-Sectional Study in Sapporo, Japan2014

    • Author(s)
      Cong S., Araki A., Ukawa S., Ait Bamai Y., Tajima S., Kanazawa A., Yuasa M., Tamakoshi A., Kishi R
    • Journal Title

      J Epidemiol

    • DOI

      10.2188/jea.JE20130135

    • Peer Reviewed
  • [Journal Article] Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants2014

    • Author(s)
      Araki A., Saito I., Kanazawa A., Morimoto K., Nakayama K., Shibata E., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R
    • Journal Title

      Indoor Air

      Volume: 24 Pages: 3-15

    • DOI

      10.1111/ina.12054

    • Peer Reviewed
  • [Journal Article] Exposure to house dust phthalates in relation to asthma and allergies in both children and adults2014

    • Author(s)
      Ait Bamai Y., Shibata E., Saito I., Araki A., Kanazawa A., Morimoto K., Nakayama K., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R
    • Journal Title

      Sci Total Environ

      Volume: 485-486C Pages: 153-163

    • DOI

      10.1016/j.scitotenv.2014.03.059

    • Peer Reviewed
  • [Journal Article] The relationship between atopic dermatitis and indoor environmental factors : a cross-sectional study among Japanese elementary school children2013

    • Author(s)
      Ukawa S., Araki A., Kanazawa A., Yuasa M., Kishi R
    • Journal Title

      Int Arch Occup Environ Health

      Volume: 86 Pages: 777-787

    • DOI

      10.1007/s00420-012-0814-0

    • Peer Reviewed
  • [Journal Article] The members of the Hokkaido Study on Environment and Children's Health.; Ten Years of Progress in the Hokkaido Birth Cohort Study on Environment and Children's Health : Cohort Profile - Updated 20132013

    • Author(s)
      Kishi R., Kobayashi S., Ikeno T., Araki A., Miyashita C., Itoh S., Sasaki S., Okada E., Kobayashi S., Kashino I., Itoh K., Nakajima S
    • Journal Title

      Environ Health Prev Med

      Volume: 18 Pages: 429-450

    • DOI

      10.1007/s12199-013-0357-3

    • Peer Reviewed
  • [Journal Article] Blood persistent organochlorine pesticides in pregnant women in relation to physical and environmental variables in The Hokkaido Study on Environment and Children's Health2012

    • Author(s)
      Kanazawa A., Miyashita C., Okada E., Kobayashi S., Washino N., Sasaki S., Yoshioka E., Mizutani F., Chisaki Y., Saijo Y., Kishi R
    • Journal Title

      Sci Total Environ

      Volume: 426 Pages: 73-82

    • DOI

      10.1016/j.scitotenv.2012.02.073

    • Peer Reviewed
  • [Journal Article] The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes2012

    • Author(s)
      Araki A., Kanazawa A., Kawai T., Eitaki Y., Morimoto K., Nakayama K., Shibata E., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R
    • Journal Title

      Sci Total Environ

      Volume: 423 Pages: 18-26

    • DOI

      10.1016/j.scitotenv.2012.02.026

    • Peer Reviewed
  • [Journal Article] 北海道の妊婦の全血中POPs系農薬の濃度環境と子どもの健康に関する北海道研究2011

    • Author(s)
      金澤文子, 宮下ちひろ, 岡田恵美子, 小林澄貴, 鷲野孝揚, 湯浅資之, 佐々木成子, 吉岡英治, 水谷太, 苣木洋一, 岸玲子
    • Journal Title

      日本衛生学雑誌

      Volume: 66 Pages: 95-107

    • URL

      http://search.jamas.or.jp/link/ui/2011192746

    • Peer Reviewed
  • [Presentation] 札幌市内小学生の自宅における暖房、および機械換気の有無と児童の喘息2013

    • Author(s)
      叢石, 荒木敦子, 鵜川重和, アイツバマイゆふ, 多島秀司, 金澤文子, et al
    • Organizer
      第65回北海道公衆衛生学会
    • Place of Presentation
      札幌
    • Year and Date
      20131114-15
  • [Presentation] 尿中フタル酸代謝物濃度とハウスダスト中フタル酸エステル濃度との関連:札幌市児童における調査2013

    • Author(s)
      アイツバマイゆふ, 荒木敦子, 河合俊夫, 坪井樹, 多島秀司, 叢石, 湯浅資之, 金澤文子, et al
    • Organizer
      第65回北海道公衆衛生学会
    • Place of Presentation
      札幌
    • Year and Date
      20131114-15
  • [Presentation] 自宅住環境とアトピー性皮膚炎に関する調査-札幌市の小学生4,500名を対象として-2011

    • Author(s)
      鵜川重和, 荒木敦子, 金澤文子, et al
    • Organizer
      第63回北海道公衆衛生学会
    • Place of Presentation
      札幌
    • Year and Date
      20111110-11
  • [Remarks] 環境健康科学研究教育センターwebサイト研究業績

    • URL

      http://www.cehs.hokudai.ac.jp/research/yearly/

  • [Remarks] 環境健康科学研究教育センター成果発信webサイト「環境と健康ひろば」

    • URL

      http://www.cehs.hokudai.ac.jp/hiroba/

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Published: 2015-07-16  

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