2013 Fiscal Year Final Research Report
Autopsy diagnosis of decompression illness in rats by quantifying pulmonary emphysema
| Project/Area Number |
23590855
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
MIYAZAKI TETSUJI 琉球大学, 医学(系)研究科(研究院), 教授 (10144825)
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| Co-Investigator(Kenkyū-buntansha) |
IHAMA Yoko 琉球大学, 医学研究科, 助教 (80347137)
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| Project Period (FY) |
2011 – 2013
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| Keywords | スキューバダイビング / 減圧症 / 法医解剖 / 剖検診断 / 肺気腫 / 脂肪塞栓 |
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| Research Abstract |
We aimed to clarify autopsy findings that would aid the diagnosis of DCI. Non-fatty and fatty rats were categorized into 3 groups: antemortem decompression group (AD), postmortem decompression group (PD), and controls, and we compared intravascular bubbles and histopathological findings. Pulmonary emphysema was quantified using ImageJ software. Intravascular bubbles were observed in both AD and PD groups. In group AD, prolonged hyperbaric exposure increased mortality, intravascular bubbles, and pulmonary emphysema, with fatty rats showing more marked changes than non-fatty rats. Intravascular bubbles and pulmonary emphysema in the dead rats were quantitatively greater. In fatty rats, pulmonary emphysema was quantitatively significantly greater in group PD than that in the dead rats of group AD. Our results indicate that the quantitative evaluation of pulmonary emphysema can potentially distinguish postmortem decompression from antemortem decompression.
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