2013 Fiscal Year Final Research Report
Effect of incretin for the liver
| Project/Area Number |
23590971
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Mie University |
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Principal Investigator |
FUJITA Naoki 三重大学, 医学部附属病院, 講師 (80378398)
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| Project Period (FY) |
2011 – 2013
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| Keywords | インクレチン / 肝細胞 / 糖代謝 / 脂質代謝 / 肝脂肪化 |
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| Research Abstract |
Incretin is a naturally occurring peptide secreted by the L or K cells of the small intestine. Incretin regulates glucose-mediated insulin and glucagon productions by pancreatic beta and alpha cells. In this study, we demonstrated that incretin has a cognate receptors on human and mouse hepatocytes and that incretin has a direct effect on the reduction of hepatic steatosis in the absence of insulin. Incretin increased the phosphorylation of PDK-1, AKT, and protein kinase C in HepG2 and Huh7 cells. Incretin-treated hepatocytes resulted in a significant increase in cAMP production as well as reduction in mRNA expression of fatty acid synthesis-related genes. Finally, incretin treatment reversed hepatis statosis in mouse, but little effect occurred in hepatic fibrosis and cell proliferation. In conclusion, our data suggest that incretin has a novel direct effect on hepatocytes glucose and fat metabolism.
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Research Products
(29 results)
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[Journal Article] Nutrition therapy using a multidiscriplinary team improves survival rates in patients with liver cirrhosis2013
Author(s)
Iwasa M, Iwata K, Hara N, Hattori A, Ishidome M, Sekiguchi-Fujikawa N, Mifuji-Moroka R, Sugimoto R, Fujita N, Kobayashi Y, Takei Y
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Journal Title
Nutrition
Volume: 29
Pages: 1418-1421
Peer Reviewed
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[Journal Article] Molecular epidemiology and genetic history of European-type genotype 3 hepatitis E virus indigenized in the central region of Japan2012
Author(s)
Nakano T, Okano H, Kobayashi M, Ito K, Ohmori S, Nomura T, Kato H, Ayada M, Nakano Y, Akachi S, Sugimoto K, Fujita N, Shiraki K, Takei Y, Takahashi M, Okamoto H
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Journal Title
Infection Genetics and Evolution
Volume: 12
Pages: 1524-1534
Peer Reviewed
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[Journal Article] New findings regarding the epidemic history and population dynamics of Japan-indigenous genotype 3 hepatitis E virus inferred by molecular evolution2012
Author(s)
Nakano T, Takahasi K, Pybus OG, Hashimoto N, Kato H, Okano H, Kobayshi M, Fujita N, Shiraki K, Takei Y, Ayada M, Arai M, Okamoto H, Mishiro S
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Journal Title
Liver Int
Volume: 32
Pages: 675-688
Peer Reviewed
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