ヘパリンコファクターIIを用いた心筋梗塞後心臓リモデリングに対する新規治療法の開発

2013 Fiscal Year Annual Research Report

• Project/Area Number: 23591046
• Research Institution: The University of Tokushima
• Principal Investigator: 岩瀬 俊 徳島大学, 大学病院, 助教 (10403718)
• Co-Investigator(Kenkyū-buntansha): 佐田 政隆 徳島大学, ヘルスバイオサイエンス研究部, 教授 (80345214) ; 原田 雅史 徳島大学, ヘルスバイオサイエンス研究部, 教授 (20228654) ; 粟飯原 賢一 徳島大学, ヘルスバイオサイエンス研究部, 講師 (70372711)
• Keywords: 心臓リモデリング / ヘパリンコファクターII

Research Abstract

急性心筋梗塞後心臓リモデリングとヘパリンコファクターIIとの関係について検討するため、①急性心筋梗塞で入院し再灌流療法を実施した症例を対象にした心臓MRI検査による各種心機能指標の解析、②急性心筋梗塞症例における血漿ヘパリンコファクターII活性の検討を行った。
急性心筋梗塞で入院し再灌流療法を実施した症例を対象にした心臓MRI検査による各種
発症後24時間以内に再灌流療法を受けた急性心筋梗塞28症例（平均年齢60歳、男性 2例）を対象に血漿ヘパリンコファクターII(HCII)活性を測定した。28症例のHCII活性は平均104%(43～141%)であり、年齢とHCII活性の間に優位な相関関係は認めなかった。心筋梗塞発症当日と約7日後の比較ではHCII活性に差は認めなかった。しかし心筋梗塞発症後に血漿ヘパリンコファクターII活性が低下する症例と、増加する症例が存在した。28症例中22例において対して心筋梗塞発症後1週間以内に心臓MRI検査を行い、更に17症例において発症後3～6ヶ月後の慢性期に心臓MRI検査を再検し、各種心機能指標の解析を行っている。左室拡張末期容積の増大ならびに左室駆出率低下などの左室リモデリングを来している症例が存在しており、今後、急性期のHCII活性および変動との関わりについて統計解析を行う。

Research Products

• [Journal Article] Augmentation Index Does Not Reflect Risk of Coronary Artery Disease in Elderly Patients (2014)
  • Author(s): Hayashi S, Yamada H, Bando M, Hotchi J, Ise T, Yamaguchi K, Iwase T, Soeki T, Wakatsuki T, Tamaki T, Sata M.
  • Journal Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 78 Pages: 1176-1182
  • DOI: 10.1253/circj.CJ-13-1422
  • Peer Reviewed
• [Journal Article] The physiological uptake pattern of (18)F-FDG in the left ventricular myocardium of patients without heart disease (2014)
  • Author(s): Nose H, Otsuka H, Otomi Y, Terazawa K, Takao S, Iwamoto S, Iwase T, Yamada H, Sata M, Harada M.
  • Journal Title: The journal of medical investigation : JMI Volume: 61 Pages: 53-58
  • Peer Reviewed
• [Journal Article] Association of lower limb muscle mass and energy expenditure with visceral fat mass in healthy men (2014)
  • Author(s): Yagi S, Kadota M, Aihara K, Nishikawa K, Hara T, Ise T, Ueda Y, Iwase T, Akaike M, Shimabukuro M, Katoh S, Sata M.
  • Journal Title: Diabetology & metabolic syndrome Volume: 6 Pages: 27
  • DOI: 10.1186/1758-5996-6-27
  • Peer Reviewed
• [Journal Article] Congenital long QT syndrome with compound mutations in the KCNH2 gene (2013)
  • Author(s): Bando S, Soeki T, Matsuura T, Niki T, Ise T, Yamaguchi K, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Akaike M, Aiba T, Shimizu W, Sata M.
  • Journal Title: Heart Vessels Volume: - Pages: -
  • DOI: 10.1007/s00380-013-0406-2
  • Peer Reviewed
• [Journal Article] A case of successful use of microsnare to hold and pull the retrograde guidewire for the intervention to peripheral chronic total occlusion (2013)
  • Author(s): Hara T, Wakatsuki T, Taketani Y, Yamaguchi K, Iwase T, Sata M.
  • Journal Title: Cardiovascular intervention and therapeutics Volume: 28 Pages: 287-90
  • DOI: 10.1007/s12928-013-0158-z
  • Peer Reviewed
• [Journal Article] Constrictive pericarditis with intrapericardial abscess (2013)
  • Author(s): Hara T, Yamada H, Takashima A, Yamasaki H, Ogasawara K, Bando S, Ise T, Niki T, Kusunose K, Ueda Y, Tomita N, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Horiguchi H, Sakashita N, Sata M.
  • Journal Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 77 Pages: 786-788
  • Peer Reviewed
• [Journal Article] Eosinophilic myocarditis due to Churg-Strauss syndrome with markedly elevated eosinophil cationic protein (2013)
  • Author(s): Hara T1, Yamaguchi K, Iwase T, Kadota M, Bando M, Ogasawara K, Bando S, Ise T, Niki T, Ueda Y, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M.
  • Journal Title: International heart journal Volume: 54 Pages: 51-53
  • Peer Reviewed
• [Journal Article] Ulcer-like projection caused by a penetrating branch to the bronchial artery (2013)
  • Author(s): Ise T, Fujioka K, Iwase T, Hotchi J, Akaike M, Sata M.
  • Journal Title: Journal of the American College of Cardiology Volume: 61 Pages: e147
  • DOI: 10.1016/j.jacc.2012.10.047
  • Peer Reviewed
• [Journal Article] Interval from the onset of transmitral flow to annular velocity is a marker of LV filling pressure (2013)
  • Author(s): Kusunose K, Yamada H, Nishio S, Tamai R, Niki T, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Sata M.
  • Journal Title: JACC. Cardiovascular imaging Volume: 6 Pages: 528-530
  • DOI: 10.1016/j.jcmg.2012.10.025
  • Peer Reviewed
• [Journal Article] Pentraxin 3 is a local inflammatory marker in atrial fibrillation (2013)
  • Author(s): Soeki T, Bando S, Uematsu E, Matsuura T, Niki T, Ise T, Kusunose K, Hotchi J, Ueda Y, Tomita N, Yamaguchi K, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
  • Journal Title: Heart Vessels Volume: - Pages: -
  • DOI: 10.1007/s00380-013-0400-8
  • Peer Reviewed
• [Journal Article] Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein (2013)
  • Author(s): Soeki T, Niki T, Uematsu E, Bando S, Matsuura T, Kusunose K, Ise T, Ueda Y, Tomita N, Yamaguchi K, Koshiba K, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Akaike M, Shimabukuro M, Kishimoto I, Kangawa K, Sata M.
  • Journal Title: Heart Vessels Volume: 28 Pages: 795-801
  • DOI: 10.1007/s00380-013-0333-2
  • Peer Reviewed
• [Journal Article] Renin-angiotensin-aldosterone system has a pivotal role in cognitive impairment (2013)
  • Author(s): Yagi S, Akaike M, Ise T, Ueda Y, Iwase T, Sata M.
  • Journal Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 36 Pages: 753-758
  • DOI: 10.1038/hr.2013.51
  • Peer Reviewed
• [Journal Article] Effects of telmisartan on inflammatory cytokines and coronary plaque component as assessed on integrated backscatter intravascular ultrasound in hypertensive patients (2013)
  • Author(s): Yamaguchi K, Wakatsuki T, Soeki T, Niki T, Taketani Y, Oeduka H, Kusunose K, Ise T, Iwase T, Yamada H, Sata M.
  • Journal Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 78 Pages: 240-247
  • Peer Reviewed
• [Journal Article] Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling (2013)
  • Author(s): Yoshida S, Aihara K, Ikeda Y, Sumitomo-Ueda Y, Uemoto R, Ishikawa K, Ise T, Yagi S, Iwase T, Mouri Y, Sakari M, Matsumoto T, Takeyama K, Akaike M, Matsumoto M, Sata M, Walsh K, Kato S, Matsumoto T.
  • Journal Title: Circulation Volume: 128 Pages: 60-71
  • DOI: 10.1161/CIRCULATIONAHA.113.001533
  • Peer Reviewed
• [Presentation] Impact of Cardiac Rehabilitation on Oxidized Stress in Patients with Heart Failure. (2014)
  • Author(s): Ise T, Yagi S, Iwase T, Akaike M, Takashima A, Bando M, Bando S, Matsuura T, Hotchi J, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuiki T, Sata M.
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京都）
  • Year and Date: 20140321-20140323
• [Presentation] 左室収縮不全を伴う心サルコイドーシスと他の心疾患鑑別におけるガドリニウム遅延造影定量評価の有用性 (2013)
  • Author(s): 岩瀬俊、高尾正一郎、赤池雅史、伊勢孝之、八木秀介、山口浩司、山田博胤、添木武、若槻哲三、西岡安彦、原田雅史、佐田政隆
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: ホテル日航熊本、熊本市現代美術館（熊本県）
  • Year and Date: 20130920-20130922
• [Presentation] 3ステラ非造影心臓MRI検査が左室内壁在血栓の検出ならびに治療方針決定に有用であった無症候性心筋虚血の1例 (2013)
  • Author(s): 岩瀬俊、高尾正一郎、太田理絵、山口浩司、赤池雅史、伊勢孝之、山田博胤、添木武、若槻哲三、原田雅史、佐田政隆
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: ホテル日航熊本、熊本市現代美術館（熊本県）
  • Year and Date: 20130920-20130922
• [Presentation] Differentiation of left ventricular systolic dysfunction related to cardiac sarcoidosis and other heart diseases using contrast-enhanced cardiovascular magnetic resonance. (2013)
  • Author(s): Iwase T, Takao T, Akaike M, Ise T, Yagi S, Yamaguchi K, Yamada H, Nishioka Y, Harada M, Sata M
  • Organizer: ESC Congress 2013
  • Place of Presentation: Amsterdam RAI (Netherlands)
  • Year and Date: 20130831-20130904