2013 Fiscal Year Final Research Report
Roles of Th9 cells in the development of allergic glanulomatous angitis and asthma
| Project/Area Number |
23591113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
HIROSE KOICHI 千葉大学, 医学(系)研究科(研究院), 准教授 (90400887)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATORI Hiroaki 千葉大学, 医学部附属病院, 助教 (30568225)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAJIMA Hiroshi 千葉大学, 大学院医学研究院, 教授 (00322024)
SUTO Akira 千葉大学, 大学院医学研究院, 特任准教授 (50447306)
IKEDA Kei 千葉大学, 医学部附属病院, 助教 (10456014)
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| Project Period (FY) |
2011 – 2013
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| Keywords | IL-25 / Th9細胞 / 肺動脈周囲炎 / 血管リモデリング |
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| Research Abstract |
Recent studies have shown that prplonged Th2-type immune inflammation in the lung induces pulmonary arterial remodeling. However, roles of IL-25, which promotes Th2-type inflammation, in the development of pulmonary arterial remodeling remain unknown. In this study, we evaluated the role of IL-25 in the development of pulmonary arterial remodeling. Repeated OVA inhalation induced pulmonary arterial wall thickening and the expression of IL-25 and RELMa mRNA in the lung in OVA-sensitized mice. Injection of neutralizing anti-IL-25 antibody inhibited OVA-induced pulmonary arterial wall thickening and RELMa expression in the lung. CC10 IL-25 mice but not CC10 IL-25 NKT-/- mice spontaneously developed pulmonary arterial wall thickening and RELMa expression in the lung at 6 months of age. These results shows that prolonged expression of IL-25 in the lung induces pulmonary arterial wall thickening by NKT cell-dependent mechanisms.
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[Journal Article] Ultrasonographic assessment predicts relapse after discontinuation of biological agents in patients with rheumatoid arthritis in clinical remission - high predictive values of total gray-scale and power Doppler scores which represent residual synovial inflammation before discontinuation2014
Author(s)
Iwamoto T, Ikeda K, Hosokawa J, Yamagata M, Tanaka S, Norimoto A, Sanayama Y, Nakagomi D, Takahashi K, Hirose K, Sugiyama T, Sueishi M, Nakajima H
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Journal Title
Arthritis Care Res
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation2011
Author(s)
Takahashi K, Hirose K, Kawashima S, Niwa Y, Wakashin H, Iwata A, Tokoyoda K, Renauld JC, Iwamoto I, Nakayama T, Nakajima H
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Journal Title
J Allergy Clin Immunol
Volume: 128
Pages: 1067-76
DOI
Peer Reviewed
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