2013 Fiscal Year Final Research Report
Activation of the prefrontal cortex is associated with exertional dyspnea in COPD
| Project/Area Number |
23591128
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TOHDA Yuji 近畿大学, 医学部, 教授 (50167524)
FUKUDA Kanji 近畿大学, 医学部, 教授 (50201744)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 閉塞性肺疾患 / 脳皮質活動 / 運動負荷 / 近赤外線分光法 / 前頭葉 |
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| Research Abstract |
Background Exertional dyspnea is the primary symptom that limits exercise for patients with chronic obstructive pulmonary disease (COPD). It is unknown which activated brain area is associated with this symptom in COPD patients.
Objectives To investigate the activation of cortical areas in COPD patients associated with dyspnea during exercise. Methods COPD patients and age-matched controls performed mild intensity constant-work rate cycle exercises for 10 minutes while cerebral hemodynamics and oxygenation were measured by near-infrared spectroscopy (NIRS). Results Oxy-Hb concentration was significantly increased in the prefrontal region during exercise in both groups, but not in temporoparietal regions. Dyspnea scores were positively correlated with changes in oxy-Hb concentrations of the prefrontal regions in both groups. Conclusions Exertional dyspnea was related to activation (oxygenation) of the prefrontal cortex in COPD patients and control subjects.
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Research Products
(19 results)
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[Presentation] Localization Of Brain Activation Associated With Dyspnea During Exercise With Respiratory Resistance : A Study Using BOLD fMRI, [Publication Page : A4907]2013
Author(s)
N. Honda, Y. Higashimoto, R. Okada, M. Onoda, K. Maeda, M. Shiraishi, R. Sugiya, S. Okajima, T. Yamagata, K. Terada, Y. Tohda, K. Fukuda
Organizer
American Thoracic Society International Conference
Place of Presentation
Pennsylvania Convention Center, Philadelphia, Pennsylvania, USA
Year and Date
2013-05-21
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[Presentation] Changes In Physical Activity After Lung Resection For Lung Cancer And Postoperative Pulmonary Rehabilitation, [Publication Page : A1806]2013
Author(s)
K. Maeda, , Y. Higashimoto, , N. Honda,, M. Shiraishi, T. Hirohata, K. Minami, T. Iwasaki, T. Yamagata, K. Terada, Y. Matsuo, Y. Tohda, K. Fukuda
Organizer
American Thoracic Society International Conference
Place of Presentation
Pennsylvania Convention Center, Philadelphia, Pennsylvania, USA
Year and Date
2013-05-19
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[Presentation] Involvement Of G Proteins In The Synergistic Effects Between Anticholinergic Agents And Beta2-Adrenoceptor Agonists In Airway Smooth Muscle, [Publication Page : A1996]2013
Author(s)
H. Kume, S. Imbe, O. Nishiyama, T. Iwanaga, Y. Higashimoto, H. Nakajima, Y. Tohda
Organizer
American Thoracic Society International Conference
Place of Presentation
Pennsylvania Convention Center, Philadelphia, Pennsylvania, USA
Year and Date
2013-05-19
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[Presentation] Effect Of Protcaterol "Assist Use" On Quality Of Life And Exercise Capacity In Patients With Chronic Obstructive Pulmonary Disease, [Publication Page : A5792]2012
Author(s)
Y. Higashimoto, H. Miyajima, H. Ichihashi, A. Sano, R. Satoh, O. Nishiyama, H. Sano, T. Yamagata, T. Iwanaga, H. Nakajima, K. Tomita, , H. Kume
Organizer
American Thoracic Society International Conference
Place of Presentation
Moscone Center, San Francisco, California, USA
Year and Date
2012-05-23
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[Presentation] Cerebral Oxygenation During Exercise In COPD Patients With And Without Exertional Desaturation, [Publication Page : A6399]2012
Author(s)
Y. Higashimoto, N. Honda, T. Yamagata, O. Nishiyama, H. Miyajima, A. Sano, H. Ichihashi, R. Satoh, H. Sano, T. Iwanaga, H. Nakajima, K. Tomita, H. Kume, Y. Tohda
Organizer
American Thoracic Society International Conference
Place of Presentation
Moscone Center, San Francisco, California, USA
Year and Date
2012-05-23
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[Presentation] Prefrontal Cortex Activation Is Associated With Dyspnea During Methacholine Bronchial Provocation Tests, [Publication Page : A4105]2012
Author(s)
Y. Higashimoto, N. Okimoto, N. Honda, T. Yamagata, R. Yamazaki, Y. Fukai, S. Innbe, H. Miyajima, H. Santoh, A. Sano, Y. Makino, R. Satoh, O. Nishiyama, H. Sano, T. Iwanaga, H. Nakajima, H. Kume, Y
Organizer
Tohda American Thoracic Society International Conference
Place of Presentation
Pennsylvania Convention Center, Philadelphia, Pennsylvania, USA
Year and Date
2012-05-21
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