2013 Fiscal Year Final Research Report
Therapeutic application of lung collectin in acute lung injury
| Project/Area Number |
23591154
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUROKI Yoshio 札幌医科大学, 医学部, 教授 (70161784)
SHIRATORI Masanori 札幌医科大学, 医学部, 准教授 (40295366)
CHIBA Hirofumi 札幌医科大学, 医学部, 講師 (40347175)
KUDO Kazumi 札幌医科大学, 医学部, 助教 (90438002)
KURONUMA Koji 札幌医科大学, 医学部, 助教 (40563250)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 急性肺障害 / ブレオマイシン / 肺コレクチン / 肺サーファクタントタンパク質A / トル様受容体 |
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| Research Abstract |
The purpose of this project were to clarify the mechanism of regulation by which Toll-like receptors (TLRs) act against drug-induced acute lung injury (ALI), to evaluate the protective effect by lung a collectin, SP-A and to establish the molecular basis for the clinical application of it. Bleomycin (BLM)-administered SP-A(-/-) mice had significantly higher mortality rate and more increase of inflammatory cytokines in the lungs than wild types. SP-A inhibited BLM-induced inflammatory cytokines from rat alveolar macrophages. sTLR2 gene-transfected HEK293 cells showed up-regulation of NF-kB. BML bound directly with sTLR2 and its binding was blocked by SP-A. These results indicate that BLM-induced signal depends on TLR2 and lung collectin, SP-A has protective function against ALI via TLR2 dependent signal pathway.
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Research Products
(35 results)
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[Journal Article] Pilot study exploring lung allograft surfactant protein A (SP-A) expression in association with lung transplant outcome2013
Author(s)
D'Ovidio F, Kaneda H, Chaparro C, Mura M, Lederer D, Di Angelo S, Takahashi H, Gutierrez C, Hutcheon M, Singer LG, Waddell TK, Floros J, Liu M, Keshavjee S
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Journal Title
Am J Transplant
Volume: 13(10)
Pages: 2722-9
DOI
Peer Reviewed
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[Journal Article] Pulmonary surfactant protein A protects lung epithelium from cytotoxicity of human β-defensin 32012
Author(s)
Saito A, Ariki S, Sohma H, Nishitani C, Inoue K, Ebata N, Takahashi M, Hasegawa Y, Kuronuma K, Takahashi H, Kuroki Y
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Journal Title
J Biol Chem
Volume: 287(18)
Pages: 15034-43
DOI
Peer Reviewed
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[Journal Article] Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling
Author(s)
Hasegawa Y, Takahashi M, Ariki S, Asakawa D, Tajiri M, Wada Y, Yamaguchi Y, Nishitani C, Takamiya R, Saito A, Uehara Y, Hashimoto J, Kurimura Y, Takahashi H, Kuroki Y
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Journal Title
DOI
Peer Reviewed
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[Presentation] Surfactant Proteins A And D Suppress Epidermal Growth Factor Signaling Through Interactions With N-Glycans Of Receptor2013
Author(s)
Hasegawa Y, Takahashi M, Ariki S, Asakawa D, Tajiri M, Wada Y, Takamiya R, Uehara Y,Hashimoto J, Takahashi H, and Kuroki Y
Organizer
18th Congress of the Asian Pacific Society of Respirology
Place of Presentation
Yokohama, Japan
Year and Date
20131111-14
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[Presentation] Subtypes of pulmonary emphysema on HRCT affect prognosis on combined pulmonary fibrosis and emphysema in idiopathic pulmonary fibrosis2013
Author(s)
Shiratori M, Yokoo K, Ikeda K, Natsuizaka M,Umeda Y, Kitamura Y, Otsuka M, Chiba H,Koba H, Takahashi H
Organizer
23th European Respiratory Society Annual Congress
Place of Presentation
Barcelona,Spain
Year and Date
20130907-11
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