Significance of high-resolution CT findings by using densitometry in patient with pulmonary alveolar proteinosis.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591160
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyorin University
• Principal Investigator: ISHII Haruyuki 杏林大学, 医学部, 講師 (30406970)
• Co-Investigator(Kenkyū-buntansha): NAKATA Koh 新潟大学, 医歯学総合病院, 教授 (80207802) ; TAZAWA Ryushi 新潟大学, 医歯学総合病院, 准教授 (70301041) ; NITADORI Toshiaki 杏林大学, 医学部, 教授 (80137512)
• Co-Investigator(Renkei-kenkyūsha): GOTO Hajime 杏林大学, 医学部, 教授 (80134617) ; YOKOYAMA Kenichi 杏林大学, 医学部, 講師 (20383680) ; HIRAOKA Sayuki 杏林大学, 医学部, 助教 (20458871)
• Project Period (FY): 2011 – 2013
• Keywords: 肺胞蛋白症 / 胸部CT / densitometry

Research Abstract

The aim of this study was to analyze the lung attenuation of ground glass opacity (GGO) by using densitometry on high-resolution CT in patients with pulmonary alveolar proteinosis (PAP). Five cases were enrolled in this study. Inspiratory thin-slice spiral chest CT scans (Aquilion 64, Toshiba medical systems, Japan) were performed. The mean lung attenuation and whole lung volume varied in each severity of PAP cases. According to the histogram feature, the ratio associated with PAP (defined as the ratio of CT lung volume for GGO divided by total CT lung volume) contributed to differentiate PAP lesion from normal area. GGO for the range of density -850 to -750 HU suggested the lesion of PAP on HRCT and the lung volume in this range showed the greatest degree correlation with the levels of serum KL-6 (r=0.867)and CEA (r=0.616). Although it is very difficult to early diagnose as PAP in generally, these results might be practical radiographic findings of diagnostic procedure for PAP.

Research Products

• [Journal Article] Secondary pulmonary alveolar proteinosis complicating myelodysplastic syndrome results in worsening of prognosis (2014)
  • Author(s): Ishii H, Seymour JF, Tazawa R, Inoue Y, Uchida N, Nishida A, Kogure Y, Saraya T, Tomii K, Takada T, Itoh Y, Hojo M, Ichiwata T, Goto H, Nakata K
  • Journal Title: BMC Pulm Med Volume: 14 Pages: 37
  • DOI: 10.1186/1471-2466-14-37
  • Peer Reviewed
• [Journal Article] Clinical features of three cases with pulmonary alveolar proteinosis secondary to myelodysplastic syndrome developed during the course of Behcet's disease (2014)
  • Author(s): Handa T, Nakatsue T, Baba M, Takada T, Nakata K, Ishii H
  • Journal Title: Respir Investig Volume: 52(1) Pages: 75-9
  • DOI: 10.1016/j.resinv.2013.05.005
  • Peer Reviewed
• [Journal Article] 続発性肺胞蛋白症の予後解析 (2013)
  • Author(s): 石井晴之
  • Journal Title: 呼吸器内科 Volume: 23(4) Pages: 342-349
  • Peer Reviewed
• [Presentation] 続発性肺胞蛋白症の臨床的特徴―全国調査結果と更なる課題― (2013)
  • Author(s): 石井晴之
  • Organizer: 日本肺サーファクタント・界面医学会第49回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-11-16
• [Presentation] Clinical characteristics of secondary pulmonary alveolar proteinosis complicated with myelodysplastic syndrome in Japan (2013)
  • Author(s): Ishii H, Tazawa R, Inoue Y, Nakata K
  • Organizer: 18^<th> Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Yokohama (oral session)
  • Year and Date: 2013-11-13
• [Presentation] Characteristics of negative GM-CSF autoantibody pulmonary alveolar proteinosis (NA-PAP) in Japan (2013)
  • Author(s): Ishii H, Nakata K, Tazawa R, Inoue Y
  • Organizer: American Thoracic Society 2013 International Conference
  • Place of Presentation: Philadelphia (Poster session)
  • Year and Date: 2013-05-20