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2013 Fiscal Year Final Research Report

Analysis on the renoprotective effects and clinical significance of endogenous Vasohibin family in chronic kidney disease

Research Project

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Project/Area Number 23591193
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionOkayama University

Principal Investigator

MAESHIMA YOHEI  岡山大学, 医歯(薬)学総合研究科, 教授 (10343287)

Co-Investigator(Renkei-kenkyūsha) SATO Yasufumi  東北大学, 加齢医学研究所腫瘍循環分野, 教授 (50178779)
Project Period (FY) 2011 – 2013
Keywords慢性腎臓病 / 血管新生 / 糖尿病性腎症 / Vasohibin-1 / 尿細管間質障害
Research Abstract

The population of CKD patients in Japan is estimated as 13.3 million people. CKD is a risk factor of end-stage renal disease and cardiovascular disorders. Here, we examined the functional role of Vasohibin-1, a negative feedback regulator of angiogenesis, in CKD. Diabetic nephropathy, tubulointerstitial injuries induced by unilateral ureteral obstruction and acute kidney injury were exacerbated in the Vasofibin-1+/-- mice compared with the wild-type mice. Renal Vasohibin-1 expression was associated with crescentic lesions and interstitial inflammation in CKD patients. Elevated plasma/urinary levels of Vasohibin-1 predicted progressive renal functional deterioration in CKD patients. These results suggest the potential renoprotective effects of Vasohibin-1 and its potential as a novel biomarker in CKD.

  • Research Products

    (10 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (2 results) Book (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein2013

    • Author(s)
      Matsuda M, Tamura K, Wakui H, Maeda A, Ohsawa M, Kanaoka T, Azushima K, Uneda K, Haku S, Tsurumi-Ikeya Y, Toya Y, Maeshima Y, Yamashita A, Umemura S
    • Journal Title

      J. Biol. Chem.

      Volume: 288巻 Pages: 19238-19249

    • DOI

      10.1074/jbc.M113.451054

    • Peer Reviewed
  • [Journal Article] Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy2012

    • Author(s)
      Tanabe K, Tamura Y, Lanaspa MA, Miyazaki M, Suzuki N, Sato W, Maeshima Y, Schreiner GF, Villarreal FJ, Johnson RJ, Nakagawa T
    • Journal Title

      Am J Physiol-Renal Physiol

      Volume: 303巻 Pages: F1264-1274

    • DOI

      10.1152/ajprenal.00227.2012

    • Peer Reviewed
  • [Journal Article] A sustained-release prostacyclin analog ONO-1301 ameliorates tubulointerstitial alterations in a mouse obstructive nephropathy model2012

    • Author(s)
      Nasu T, Kinomura M, Tanabe K, Yamasaki H, Htay SL, Saito D, Hinamoto N, Watatani H, Ujike H, Suzuki Y, Sugaya T, Sugiyama H, Sakai Y, Matsumoto K, Maeshima Y, Makino H
    • Journal Title

      Am J Physiol-Renal Physiol

      Volume: 302巻 Pages: F1616-1629

    • DOI

      10.1152/ajprenal.00538.2011

    • Peer Reviewed
  • [Journal Article] Amelioration of renal alterations in obese type 2 diabetic mice by Vasohibin-1, a negative feedback regulator of angiogenesis2011

    • Author(s)
      Saito D, Maeshima Y, Nasu T, Yamasaki H, Tanabe K, Sugiyama H, Sonoda H, Sato Y, Makino H
    • Journal Title

      Am J Physiol-Renal Physiol

      Volume: 300巻 Pages: F873-886

    • DOI

      10.1152/ajprenal.00503.2010

    • Peer Reviewed
  • [Journal Article] Renal distribution of Vasohibin-1 in patients with chronic kidney disease

    • Author(s)
      Hinamoto N, Maeshima Y, Saito D, Yamasaki H, Tanabe K, Nasu T, Watatani H, Ujike H, Kinomura M, Sugiyama H, Sonoda H, Kanomata N, Sato Y, Makino H
    • Journal Title

      Acta Medica Okayama

      Volume: (In press)

    • Peer Reviewed
  • [Presentation] Protective Effects of Endogenous Vasohibin-1 on Podocyte in Diabetic Nephropathy2013

    • Author(s)
      Hinamoto N (Maeshima Y)
    • Organizer
      2013年度米国腎臓学会議
    • Place of Presentation
      アトランタ、米国
    • Year and Date
      2013-11-07
  • [Presentation] Lack of Vasohibin-1 exacerbates tubulo- interstitial injuries partly via activating Smad3 and excessive matrix production in renal fibroblasts2012

    • Author(s)
      Watatani H (Maeshima Y)
    • Organizer
      2012年度米国腎臓学会議
    • Place of Presentation
      サンディエゴ,米国
    • Year and Date
      2012-11-01
  • [Book] CKDフォトブック2013

    • Author(s)
      槇野博史、前島洋平
    • Total Pages
      51
    • Publisher
      シスメックス株式会社
  • [Patent(Industrial Property Rights)] バゾヒビン含有治療剤2013

    • Inventor(s)
      前島洋平、那須達世、田邊克幸、 佐藤靖史、槇野博史
    • Industrial Property Rights Holder
      国立大学法人 岡山大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      第5256192号
    • Filing Date
      2013-04-26
    • Overseas
  • [Patent(Industrial Property Rights)] 糖尿病性腎症の治療用医薬組成物2012

    • Inventor(s)
      前島洋平,一瀬邦弘,槇野博史
    • Industrial Property Rights Holder
      国立大学法人 岡山大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      第5044775号
    • Filing Date
      2012-07-27
    • Overseas

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Published: 2015-07-16  

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