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2013 Fiscal Year Final Research Report

Analysis of paracellular sodium ion transport in the thin ascending limb of Henle's loop

Research Project

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Project/Area Number 23591211
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionNihon University

Principal Investigator

MORIMOTO TETSUJI  日本大学, 医学部, 助教 (10344657)

Co-Investigator(Kenkyū-buntansha) KONDO Yoshiaki  日本大学, 医学部, 教授 (00221250)
UCHIDA Shinichi  東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (50262184)
Project Period (FY) 2011 – 2013
Keywords細いヘンレの上行脚 / 細胞間隙 / ナトリウムイオン輸送
Research Abstract

We analyzed paracellular sodium ion transport mechanism in the thin ascending limb, which plays an important role in mammalian urine-concentrating mechanism, using in vitro microperfusion technique. We examined whether aldosterone and insulin affected the transepithelial voltages or not. However, the transepithelial voltages remained unchanged. These results meant that both of them did not affect a sodium ion transport in this segment. Besides, according to just a few experiments, insulin like growth factor - 1 also suggested the same result.

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Published: 2015-07-16  

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