2013 Fiscal Year Final Research Report
Establishment of iPS cells derived from the patients with Kii ALS/PDC and proliferation from iPS cells to neuronal cells
Project/Area Number |
23591242
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Mie University |
Principal Investigator |
KOKUBO YASUMASA 三重大学, 地域イノベーション学研究科, 招へい教授 (60263000)
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Co-Investigator(Kenkyū-buntansha) |
KUZUHARA Sigeki 鈴鹿医療科学大学, 保健衛生学部, 教授 (70111383)
HIROKAWA Yoshifumi 三重大学, 大学院医学系研究科, 講師 (30322738)
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Co-Investigator(Renkei-kenkyūsha) |
ERA Takumi 熊本大学, 発生医学研究所, 教授 (00273706)
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Project Period (FY) |
2011 – 2013
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Keywords | 紀伊半島 / ALS/PDC / iPS細胞 / 神経変性疾患 |
Research Abstract |
Disease-specific iPS cells have been established from T cells derived from the five patients with Kii ALS/PDC. The efficiency of establishment and speed of proliferation were different among cases. We are going to select iPSC clones for differentiation to neuronal cells and glia cells, and analyze them to reveal pathology and create a new treatment for Kii ALS/PDC.
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Research Products
(22 results)
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[Journal Article] Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS2013
Author(s)
Kotaro Ogaki,Yuanzhe Li,Masashi Takanashi,Kei-Ichi Ishikawa,Tomonori Kobayashi,Takashi Nonaka,Masato Hasegawa, Masahiko Kishi,Hiroyo Yoshino,Manabu Funayama,Tetsuro Tsukamoto,Keiichi Shioya, Masayuki Yokochi,Hisamasa Imai,Ryogen Sasaki,Yasumasa Kokubo,Shigeki Kuzuhara,Hiroyuki Tomiyama,,Nobutaka Hattori
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Journal Title
Parkinsonism Relat Disord
Volume: 19(1)
Pages: 15-20
Peer Reviewed
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[Journal Article] Environmental Characteristics and oidative stress of inhabitants and patinets with amyoyrophic lateral sclerosis in a high-incidence area on the Kii peninsula, Japan2013
Author(s)
Tameko Kihira, Kazushi Okamoto, Sohei Yoshida, Tetuya Kondo, Keiko Iwai, Sachiko Wada, Yoshinori Kajimoto, Tomoyoshi Kondo, Yasumasa Kokubo, Shigeki Kuzuhara
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Journal Title
Internal Medicine
Volume: 52
Pages: 1479-1486
Peer Reviewed
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[Journal Article] Rare case of disseminated cysticercosis and taeniasis in a Japanese traveller after returning from India2013
Author(s)
Ken-ichiro Kobayashi, Fukumi Nakamura-Uchiyama, Takeshi Nishiguchi, Kenichi Isoda, Yasumasa Kokubo, Katsuhiko Ando, Masaki Katurahara, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Sentaro Iwabuchi, and Kenji Ohnishi
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Journal Title
Am J Trop Med Hyg
Volume: 89(1)
Pages: 58-62
Peer Reviewed
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[Journal Article] α-Synuclein Pathology in Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex in the Kii Peninsula, Japan2012
Author(s)
Kokubo Y, Taniguchi A, Hasegawa M, Hayakawa Y, Morimoto S, Yoneda M, Hirokawa Y, Shiraishi T, Saito Y, Murayama S, Kuzuhara S
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Journal Title
J Neuropathol Exp Neurol
Volume: 71
Pages: 625-630
Peer Reviewed
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[Journal Article] Mutational analysis of familial and sporadic amyotrophic lateral sclerosis with OPTN mutations in Japanese population2012
Author(s)
Naruse H, Takahashi Y, Kihira T, Yoshid S, Kokubo Y, Kuzuhara S, Ishiura H, Amagasa M, Murayama S, Tsuji S, Goto J
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Journal Title
Amyotroph Lateral Scler
Volume: 13
Pages: 562-566
Peer Reviewed
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[Journal Article] An increase in ALS incidence on the Kii Peninsula, 1960-2009: A possible link to change in drinking water source2012
Author(s)
Tameko Kihira, S Yoshida, T Kondo, K Iwai, S Wada, S Morinaga, Y Kazimoto, T Kondo, K Okamoto, Y Kokubo, S Kuzuhara
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Journal Title
Amyotrophic Lateral Sclerosis
Volume: 13
Pages: 347-350
Peer Reviewed
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[Journal Article] PLA2G6 variant in Parkinson's disease2011
Author(s)
Hiroyuki Tomiyama, Hiroyo Yoshino, Kotaro Ogaki, Lin Li, Chikara Yamashita, Yuanzhe Li, Manabu Funayama, Ryogen Sasaki, Yasumasa Kokubo, Shigeki Kuzuhara, and Nobutaka Hattori
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Journal Title
J Hum Genet
Volume: 56(5)
Pages: 401-403
Peer Reviewed
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[Presentation] Transitional metal contents in scalp hair and lifestyle of ALS patients and residents in the Kii Peninsula, Japan -the second report-2013
Author(s)
Tameko Kihira, Iori Sakurai, Sohei Yoshida, Ikuro Wakayama, Koichi Takamiya, Yukihiro Nakano, Ryo Okumura, Iinuma Yuhto, Keiko Iwai, Junko Kohmoto, Yoshinori Kajimoto, Yasuhiro Hiwatani, Kazushi Okamoto, Yasumasa Kokubo, Shigeki Kuzuhara
Organizer
24th International Symposium on ALS/MND
Place of Presentation
Milan,Italy
Year and Date
20131206-08
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[Presentation] Alfa-Synuclein pathology of amyotrophic lateral sclerosis/parkinsonism-dementia complex in the Kii Peninsula, Japan2012
Author(s)
Yasumasa Kokubo, Akira Taniguchi, Masato Hasegawa, Yuma Hayakawa, Satoru Morimoto, Misao Yoneda, Yoshihumi Hirokawa, Taizo Shiraishi, Yuko Saito, Shigeo Murayama, Shigeki Kuzuhara
Organizer
The 8^<th> International Conference on Frontotemporal dementias
Place of Presentation
Manchester, UK
Year and Date
20120905-07
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