2013 Fiscal Year Final Research Report
Glucose metabolism in ghrelin conditional KO mice
| Project/Area Number |
23591320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YADA Toshihiko 自治医科大学, 医学部, 教授 (60166527)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 糖代謝 / インスリン分泌 / グレリン |
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| Research Abstract |
Ghrelin reportedly restricts insulin release in islet b-cells via Gi-proteins and thereby regulates glucose homeostasis. This study explored whether ghrelin regulates cAMP signaling and whether this regulation induces insulinostatic cascade in islet b-cells. Furthermore, this study aimed to clarify whether ghrelin counteracts effects of GLP-1, a physiological incretin hormone that promote glucose-induced insulin release in rat islet b-cells.
Ghrelin directly interacts with b-cells to attenuate glucose-induced cAMP production and PKA activation, which lead to activation of Kv channels and suppression of glucose-induced [Ca2+]i increase and insulin release. Ghrelin potently attenuates GLP-1-induced cAMP production, [Ca2+]i increases and insulin release in b-cells. These findings indicate that interaction between ghrelin and GLP-1 plays an important role in physiological regulation of glucose-induced insulin release.
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[Journal Article] Involvement of cAMP-EPAC-TRPM2 activation in glucose- and incretin-induced insulin secretion2014
Author(s)
Yoshida M, Dezaki K, Uchida K, Kodera S, Lam NV, Ito K, Rita RS, Yamada H, Shimomura K, Ishikawa SE, Sugawara H, Kawakami M, Tominaga M, Yada T, Kakei M
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Journal Title
Diabetes
Volume: (Epub ahead of print)
DOI
Peer Reviewed
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