2014 Fiscal Year Final Research Report
Leukemogenic property of acute promyelocytic leukemia gene, BCOR-RARA
| Project/Area Number |
23591410
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
|
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| Research Institution | Fujita Health University |
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Principal Investigator |
|
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| Project Period (FY) |
2011-04-28 – 2015-03-31
|
| Keywords | 急性骨髄性白血病 / 急性前骨髄性白血病 / BCOR / RARA |
|---|
| Outline of Final Research Achievements |
32D cell lines with BCOR-RARA exhibited differentiation block under G-CSF condition, however ATRA administration induced myeloid differentiation. Whole exome sequences with t(X;17)(p11;q12) APL samples revealed no additional gene mutations except BCOR-RARA. Deep sequence by next generation sequence of BCOR region detected 5 different BCOR mutations from 4 samples. Taken together, BCOR has important roles as a tumor suppressor.
|
| Free Research Field |
血液腫瘍学
|
