2013 Fiscal Year Final Research Report
The role of IL-25 receptor expressed on eosinophil lineage-committed progenitor
| Project/Area Number |
23591463
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AKASHI Koichi 九州大学, 大学院医学研究院, 教授 (80380385)
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| Project Period (FY) |
2011 – 2013
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| Keywords | IL-25 / IL-33 / 好酸球前駆細胞 |
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| Research Abstract |
Recently, we revealed that eosinophil lineage-committed progenitor (EoP) express both receptors for IL-25 and IL-33, which are members of epithelial cell-derived cytokines, but the role of these rececptors remain unknown. IL-33 stimulated EoP produced Th2 and pro-inflammtory cytokines, such as IL-4, 6, 13, suggesting that IL-33-stimulated EoP may serve not only as progenitor cell in eosinophil development but also as effector cell in allergic inflammation. Intraperitoneal administration of IL-25 and IL-33 induced the exclusive expansion of EoP and mature eosinophils, suggesting that both cytokines should be critical regulators in eosinophil hematopoiesis.
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