2013 Fiscal Year Final Research Report
Study on immunotherapy of the intractable EB virus infectious disease using the humanized animal model
| Project/Area Number |
23591572
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHII Eichi 愛媛大学, 大学院医学系研究科, 教授 (20176126)
EGUSHI Mariko 愛媛大学, 大学院医学系研究科, 准教授 (40420781)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 細胞傷害活性 / T細胞クローン / EBウイルス |
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| Research Abstract |
Among the Japanese children with Chediak-Higashi syndrome who have or dont have hemophagocytic lymphohistiocytosis (HLH) registered at our laboratory. We analyzed the cytotoxicity and degranulation activity of CTLs. In Chediak-Higashi syndrome who have hemophagocytic lymphohistiocytosis In HLH positive patient with CTL-mediated cytotoxicity was low or deficient, and degranulation activity was also low .
Chediak-Higashi syndrome who have hemophagocytic lymphohistiocytosis can be diagnosed and classified on the basis of CTL-mediated cytotoxicity, degranulation activity, and genetic analysis. Based on the data obtained from functional analysis of CTLs.
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Research Products
(18 results)
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[Journal Article] Suppression of the let-7b microRNA pathway by DNA hypermethylation in infant acute lymphoblastic leukemia with MLL gene rearrangements2013
Author(s)
Nishi M, Eguchi-Ishimae M, Wu Z, Gao W, Iwabuki H, Kawakami S, Tauchi H, Inukai T, Sugita K, Hamasaki Y, Ishii E, Eguchi M.
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Journal Title
Leukemia
Volume: 27
Pages: 389-397
DOI
Peer Reviewed
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[Journal Article] Salvage allogeneic hematopoietic SCT for primary graft failure in children2013
Author(s)
Kato M, Matsumoto K, Suzuki R, Yabe H, Inoue M, Kigasawa H, Inagaki J, Koh K, Hashii Y, Tauchi H, Suminoe A, Kikuta A, Sakamaki H, Kawa K, Kato K, Fukuda T.
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Journal Title
Bone Marrow Transplant
Volume: 48
Pages: 1173-1178
DOI
Peer Reviewed
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[Journal Article] Nationwide survey of bisphosphonate therapy for children with reactivated Langerhans cell histiocytosis in Japan2011
Author(s)
Morimoto A, Shioda Y, Imamura T, Kanegane H, Sato T, Kudo K, Nakagawa S, Nakadate H, Tauchi H, Hama A, Yasui M, Nagatoshi Y, Kinoshita A, Miyaji R, Anan T, Yabe M, Kamizono J.
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Journal Title
Pediatr Blood Cancer
Volume: 56
Pages: 110-115
DOI
Peer Reviewed
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[Journal Article] Outcome of unrelated umbilical cord blood transplantation in 88 patients with primary immunodeficiency in Japan2011
Author(s)
Morio T, Atsuta Y, Tomizawa D, Nagamura-Inoue T, Kato K, Ariga T, Kawa K, Koike K, Tauchi H, Kajiwara M, Hara T, Kato S.
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Journal Title
Br J Haematol
Volume: 154
Pages: 363-372
DOI
Peer Reviewed
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