2013 Fiscal Year Final Research Report
JNK is Critical for Development of Candida albicans-induced Aneurysm in Mouse Model of Kawasaki Disease
| Project/Area Number |
23591590
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Kyoko (IMANAKA Kyoko) 三重大学, 医学系研究科, 准教授 (00242967)
YOSHIMURA Koichi 山口県立大学, 看護栄養学部, 教授 (00322248)
KOGA Mitsuhisa 福岡大学, 薬学部, 助教 (60570801)
CHO Tamaki 福岡歯科大学, 歯学部, 准教授 (90131870)
HASHIMOTO Junichi 福岡大学, 医学部, 助教 (90580291)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 川崎病 / 冠動脈瘤 / カンジダアルビカンス / JNK / テネイシンC |
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| Research Abstract |
We injected Candida albicans cell wall extract (CAWE) into 4-week-old C57BL/6 mice intraperitoneally, and found that CAWE caused the development of aneurysms at coronary artery, carotid artery, celiac artery, iliac artery and abdominal aorta. Histological examination of coronary artery and abdominal aorta in CAWE-treated mice showed marked inflammatory cell infiltration, destruction of elastic lamellae, loss of medial smooth muscle cells and intimal thickening, which are similar to histological features of vascular lesions of patients with KD. To find the role of JNK in aneurysm development, we evaluated the effects of JNK inhibitor, SP600125, on abdominal aortic aneurysms induced by CAWE. Ttreatment with SP600125 significantly decreased the incidence of aneurysm and also protected against vascular inflammation and tissue destruction histologically, compared with the placebo treatment. JNK potential represents novel therapeutic target for aneurysms in Kawasaki disease.
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