2013 Fiscal Year Final Research Report
Strategy for the development of novel treatment for alopecia areata via chemokine and chemokine receptors
| Project/Area Number |
23591642
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
ITO TAISUKE 浜松医科大学, 医学部附属病院, 講師 (90293638)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 皮膚炎症・再生学 |
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| Research Abstract |
Prominent accumulation of lymphocytes is seen in the lesion of alopecia areata. These infiltrated cells are composed by Th1 and Tc1 cells. Th1 and Tc1 chemokine, such as CXCL10, is prominently expressed in hair bulbs of alopecia areata, and Th1 and Tc1 cells accumulate toward CXCL10 positive hair bulbs. The accumulation of CD8+ T cells is found not only acute phase of alopecia areata but also chronic phase of alopecia areata lesions. Inhibition of chemotaxis against CXCL10 can be new candidate of the treatment of alopecia areata. The Japanese guideline of alopecia areata suggests anti histaminic drugs. In this study, we reported that anti-histaminic drugs possess anti-chemotactic effects.
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