2013 Fiscal Year Final Research Report
Investigation of expression regulation and pathological mechanism of Panton-valentine leukocidine in skin
| Project/Area Number |
23591646
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORIZANE Shin 岡山大学, 大学病院, 助教 (80423333)
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| Co-Investigator(Renkei-kenkyūsha) |
KANEKO Jun 東北大学, 農学研究科, 准教 (30221188)
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| Project Period (FY) |
2011 – 2013
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| Keywords | パントンバレンタインロイコシジン / 皮膚細菌感染症 / せつ / 好中球 / 黄色ブドウ球菌 |
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| Research Abstract |
Panton-Valentine leukocidin (PVL) is a cytotoxin produced by Staphylococcus aureus, PVL exhibits very highly specific lytic activity against polymorphonuclear cells of human and rabbits. PVL gene-positive S. aureus is strongly associated with furunculosis and community-acquired necrotic pneumonia. We demonstrated PVL gene-positive S. aureus strains are involved in the development of multiple furuncles with more intense erythema, particularly in healthy young adults. However, the role of PVL in the development of furunculosis has not been fully elucidated. We analyzed regulatory factors of PVL toxin production and of the influence of PVL on keratinocytes, fibroblasts and endothelial cells. In addition, we investigated about PVL-carrying phage type in furunculosis.
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Research Products
(15 results)
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[Journal Article] Acne-associated syndromes: models for better understanding of acne pathogenesis2011
Author(s)
Chen W, Obermayer-Pietsch B, Hong JB,Melnik BC, Yamasaki O, Dessinioti C,Ju Q, Liakou AI, Al-Khuzaei S,Katsambas A, Ring J, Zouboulis CC
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Journal Title
J Eur Acad Dermatol Venereol
Volume: 25(6)
Pages: 637-46
Peer Reviewed
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