Combination of indocyanine green and gold nano-particles for diagnosis and treatment of tumors and vascular abnormality

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591663
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: National Defense Medical College
• Principal Investigator: AZUMA Ryuichi 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 講師 (00531112)
• Co-Investigator(Kenkyū-buntansha): KIYOSAWA Tomoharu 防衛医科大学校病院, 准教授 (90221217) ; MORIMOTO Yuji 防衛医科大学校, 医学科専門課程, 准教授 (10449069)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: インドシアニングリーン / 金ナノロッド / 近赤外レーザー

Outline of Final Research Achievements

Infrared laser irradiation after intravenous administration of indocyanine green increases vascular permeability at skin and dermo-muscular layer of rats. Subsequently induced intravenous gold nano-rods and infrared laser irradiation effectively injure skin and subcutaneous tissue. This indicates that GNRs would be highly concentrated in the tissue by EPR effect. The effect exerts intensely at superficial layer of the skin and is unaffected by blood flow. Thus, this method could be available for drug delivery system on tissues which have poor blood flow.

Free Research Field

形成外科学