2013 Fiscal Year Final Research Report
Evaluation of intravascular behavior and optimization of embolization microspheres for the paradigm shit of vascular embolotherapy
| Project/Area Number |
23591819
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
OSUGA Keigo 大阪大学, 医学(系)研究科(研究院), 講師 (90332741)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Noboru 大阪大学, 大学院医学系研究科, 助教 (00506488)
HIGASHIHARA Hiroki 大阪大学, 大学院医学系研究科, 助教 (90423186)
HIDAKA Kuniyuki 大阪大学, 医学部附属病院医療技術部放射線部, その他 (50437430)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血管塞栓術 / 血管塞栓物質 / 球状ビーズ |
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| Research Abstract |
We developed a vessel phantom with variable flow-velocity for simulating intravascular behavior of embolization microspheres. The in-vivo study using canine models suggested that optimal embolization endpoint was different among mechanical properties of microspheres in addition to the target organ and purpose of embolization. To achieve the total ischemia of parenchyma organs like the kidney, complete embolization using microspheres with high elasticity and high viscoelasticity seemed necessary. To minimize the ischemic damage of hollow organs like the small intestine, limited embolization with microspheres equal to or larger than 500 micron seemed appropriate.
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