2013 Fiscal Year Final Research Report
High precision radiotherapy considering the risk of recurrence and complication for cervical cancer
| Project/Area Number |
23591833
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
OHNO Tatsuya 群馬大学, 重粒子線医学推進機構, 教授 (10344061)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Shingo 埼玉医科大学, 医学部, 教授 (00370875)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 子宮頸癌 / 放射線治療 / 重粒子線治療 / 再発リスク / 画像誘導下 |
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| Research Abstract |
The purpose of the study was to develop high precision radiotherapy considering the risk of recurrence and complication and to promote the personalized treatment for uterine cervical cancer. The major research included image-guided brachytherapy (IGBT) for primary tumor, control of pelvic lymph node metastases, and comparison of intensity-modulated radiotherapy (IMRT) with conventional 3D conformal radiotherapy.
In the IGBT, increasing or decreasing of point A dose balanced sufficient dose between rectum and target. In case of irregular-shaped bulky tumor, hybrid brachytherapy consisting of conventional application and interstitial needle was effective to cover the tumor with sufficient dose while sparing the rectal dose. We also clarified the pelvic control dose and the sparing effect of small intestine and pelvic bone doses by IMRT.
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[Journal Article] Distribution patterns of metastatic pelvic lymph nodes assessed by CT/MRI in patients with uterine cervical cancer2013
Author(s)
Kasuya G, Toita T, Furutani K, Kodaira T, Ohno T, Kaneyasu Y, Yoshimura R, Uno T, Yogi A, Ishikura S, Hiraoka M
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Journal Title
Radiat Oncol
Volume: 8
Pages: 139
Peer Reviewed
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[Journal Article] Long-term Follow-up Results of a Multi-institutional Phase 2 Study of Concurrent Chemoradiation Therapy for Locally Advanced Cervical Cancer in East and Southeast Asia2013
Author(s)
Kato S, Ohno T, Thephamongkhol K, Chansilpa Y, Cao J, Xu X, Devi CR, Swee TT, Calaguas MJ, de Los Reyes RH, Cho CK, Dung TA, Supriana N, Erawati D, Mizuno H, Nakano
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 87
Pages: 100-5
Peer Reviewed
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[Journal Article] Insufficiency fractures after pelvic radiation therapy for uterine cervical cancer : an analysis of subjects in a prospective multi-institutional trial, and cooperative study of the Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG)2012
Author(s)
Tokumaru S, Toita T, Oguchi M, Ohno T, Kato S, Niibe Y, Kazumoto T, Kodaira T, Kataoka M, Shikama N, Kenjo M, Yamauchi C, Suzuki O, Sakurai H, Teshima T, Kagami Y, Nakano T, Hiraoka M, Mitsuhashi N, Kudo S
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 84
Pages: e195-200
Peer Reviewed
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[Journal Article] JCOG Radiation Therapy Study Group. A consensus-based guideline defining clinical target volume for primary disease in external beam radiotherapy for intact uterine cervical cancer2011
Author(s)
Toita T, Ohno T, Kaneyasu Y, Kato T, Uno T, Hatano K, Norihisa Y, Kasamatsu T, Kodaira T, Yoshimura R, Ishikura S, Hiraoka M
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Journal Title
Jpn J Clin Oncol
Volume: 41
Pages: 1119-26
Peer Reviewed
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[Journal Article] Genetic variants of NPAT-ATM and AURKA are associated with an early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy2011
Author(s)
Ishikawa A, Suga T, Shoji Y, Kato S, Ohno T, Ishikawa H, Yoshinaga S, Ohara K, Ariga H, Nomura K, Shibamoto Y, Ishikawa K, Moritake T, Michikawa Y, Iwakawa M, Imai T
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 81
Pages: 1144-52
Peer Reviewed
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