Research on inhibition of anti-cancer treatment-induced EMT and fibrosis in the background liver and hepatocellular carcinoma

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591981
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kanazawa University
• Principal Investigator: TAJIMA HIDEHIRO 金沢大学, 大学病院, 助教 (00436825)
• Co-Investigator(Kenkyū-buntansha): OHTA Tetsuo 金沢大学, 医学系, 教授 (40194170)
• Project Period (FY): 2011 – 2013
• Keywords: 上皮間葉転換 / 癌幹細胞 / 肝星細胞 / 癌間質 / 肝癌

Research Abstract

Epithelial-mesenchymal transition (EMT) in tissue fibrosis and cancer metastasis and invasion has been noted, but the EMT is induced in cancer cells by anti-cancer therapy itself has become a hot topic in recent years. It is well known that tissue fibrosis and EMT are inhibited by low dose administered taxan and histone deacetylase (HDAC) inhibitor. It has been shown that paclitaxel suppresses the induction of EMT in primary liver cancer (intrahepatic cholangiocarcinoma) cell line in the current study, HDAC inhibitors (sodium valproate) and paclitaxel inhibited activation of hepatic stellate cells.

Research Products

• [Journal Article] Low-dose paclitaxel inhibits the induction of epidermal-mesenchymal transition in the human cholangiocarcinoma CCKS-1 cell line (2013)
  • Author(s): Hirose A, Tajima H, Ohta T, Tsukada T, Okamoto K, Nakanuma S, Sakai S, Kinoshita J, Makino I, Furukawa H, Hayashi H, Nakamura K, Oyama K, Inokuchi M, Nakagawara H, Miyashita T, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Fujimura T, Harada S.
  • Journal Title: Oncol Let. Volume: 6 Pages: 915-920
  • DOI: 10.3892/ol.2013.1494
  • Peer Reviewed
• [Journal Article] Angiotensin II enhances epithelial- to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal cell-derived factor-1/CXCR4 axis in intrahepatic cholangiocarcinoma (2012)
  • Author(s): Okamoto K, Tajima H, Nakanuma S, Sakai S, Makino I, Kinoshita J, Hayashi H, Nakamura K, Oyama K, Nakagawara H, Fujita H, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Fujimura T, Harada S, Wakayama T, Iseki S, Ohta T.
  • Journal Title: Int J Oncol. Volume: 41 Pages: 573-582
  • DOI: 10.3892/ijo.2012.1499
  • Peer Reviewed
• [Journal Article] Sodium valproate blocks the transforming growth factor (TGF)-β1 autocrine loop and attenuates the TGF-β1-induced collagen synthesis in a human hepatic stellate cell line (2011)
  • Author(s): Watanabe T, Tajima H, Hironori H, Nakagawara H, Ohnishi I, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Tani T, Fujimura T, Ohta T, Wakayama T, Iseki S, Harada S.
  • Journal Title: Int J Mole Med. Volume: 28 Pages: 919-925
  • DOI: 10.3892/ijmm.2011.768
  • Peer Reviewed
• [Presentation] 胆道癌に対するlow dose Paclitaxel療法の基礎的検討 (2013)
  • Author(s): 田島秀浩、真橋宏幸、廣瀬淳史、渡邊利史、岡本浩一、中沼伸一、正司政寿、牧野勇、林泰寛、尾山勝信、中川原寿俊、宮下知治、高村博之、北川裕久、太田哲生
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2013-10-24
• [Presentation] 胆道癌に対するlow dose Paclitaxel療法の上皮間葉転換(EMT)抑制に関する実験的検討および臨床的効果 (2013)
  • Author(s): 田島秀浩、太田哲生、中沼伸一、岡本浩一、酒井清祥、牧野勇、林泰寛、尾山勝信、中川原寿俊、宮下知治、高村博之、二宮致、北川裕久、伏田幸夫、藤村隆
  • Organizer: 第49回日本胆道学会学術集会
  • Place of Presentation: ヒルトン東京ベイ(千葉県)
  • Year and Date: 2013-09-20
• [Presentation] Experimental research on effect of low-dose paclitaxel for fibrosis in human hepatic stellate cells (2013)
  • Author(s): 真橋宏幸、田島秀浩、廣瀬淳史、渡邉利史、岡本浩一、中沼伸一、酒井清祥、林泰寛、中川原寿俊、高村博之、二宮致、北川裕久、伏田幸夫、藤村隆、太田哲生
  • Organizer: 第22回日本がん転移学会学術集会
  • Place of Presentation: ホテルブエナビスタ(長野県)
  • Year and Date: 2013-07-12
• [Presentation] Low-dose paclitaxel inhibits the induction of EMT in a human cholangiocarcinoma cell line, CCKS-1 (2012)
  • Author(s): 廣瀬淳史、田島秀浩、牧野勇、中村慶史、林泰寛、尾山勝信、井口雅史、中川原寿俊、藤田秀人、高村博之、二宮致、北川裕久、藤村隆、太田哲生
  • Organizer: 第21回日本がん転移学会学術集会/総会
  • Place of Presentation: オリエンタルホテル広島(広島県)
  • Year and Date: 2012-07-12