2013 Fiscal Year Final Research Report
Role of ARNT-Hypoxia Inducible Factor 1 in development of pulmonary arterial hypertension
| Project/Area Number |
23592039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SUGANO Mikio 徳島大学, 大学病院, 医員 (70563807)
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Tetsuya 徳島大学, ヘルスバイオサイエンス研究部, 教授 (80240886)
KUROBE Hirotsugu 徳島大学, ヘルスバイオサイエンス研究部, 助教 (30380083)
NAKAYAMA Taisuke 徳島大学, 大学病院, 医員 (80582791)
FUJIMOTO Eiki 徳島大学, 大学病院, 特任助教 (60611225)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肺高血圧症 / ARNT-HIF1 / 低酸素応答 |
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| Research Abstract |
Hypoxia-inducible factor (HIF) specifically in endothelial cells of the pulmonary artery seems to play an important role in development of pulmonary arterial hypertension. Role of HIF was investigated using monocrotaline-induced pulmonary arterial hypertension model mice lacking Hif-1 beta. The endothelin upregulation through HIF may be one of the potential pathways for the pulmonary artery remodeling in the lung tissue.
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