2013 Fiscal Year Final Research Report
Next generation sequencing of a large pedigree with intracranial aneurysms
| Project/Area Number |
23592108
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ONDA Hideaki 東京女子医科大学, 医学部, 非常勤講師 (60185692)
YONEYAMA Taku 東京女子医科大学, 医学部, 助教 (90318105)
AKAGAWA Hiroyuki 東京女子医科大学, 医学部, 准教授 (60398807)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳動脈瘤 / 感受性遺伝子 / 次世代シーケンサー |
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| Research Abstract |
Recent advances in sequencing technologies, in particular the next generation sequencing (NGS), have led us to focus on rare variant mapping together with a renewed interest in a familial linkage analysis. In the present study, we successfully identified susceptibility genes for intracranial aneurysms (IA) using NGS in combination with a linkage analysis of a large IA pedigree. These susceptibility genes were associated with molecular causes of atherosclerosis or polycystic kidney disease, both known to be initiating IA formation.
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