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2013 Fiscal Year Final Research Report

Development of photodynamic therapy targeted at glioma stem cells

Research Project

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Project/Area Number 23592147
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionOsaka Medical College

Principal Investigator

KUROIWA Toshihiko  大阪医科大学, 医学部, 教授 (30178115)

Co-Investigator(Kenkyū-buntansha) KAJIMOTO Yoshinaga  大阪医科大学, 医学部, 講師 (30224413)
Project Period (FY) 2011 – 2013
Keywords光線力学治療 / 5-アミノレブリン酸 / ポルフィリン / 脳腫瘍 / 悪性グリオーマ / がん幹細胞 / ABCG2
Research Abstract

Cancer stem cells is a main cause of resistance of various cancer therapies. ABCG2 transporter, which is highly express in cancer stem cells, also transport excessive porphyrin to extra-cellular space. Therefore, controlling ABCG2 may enhance the effect of 5-ALA PDT and may control cancer stem cells.
In this study, we found that more than a half of porphyrin by produced by 5-ALA administration transported to extracellular space, and inhibition of ABCG2 transporter increased intra-cellular porphyrin and enhanced 5-ALA PDT effect. Furthermore, A172 glioma stem cell had a nature of 5-ALA PDT sensitivity, rather than resistance. These results indicated that 5-ALA PDT and/or combined with ABCG2 inhibitor may useful for controlling the cancer stem cells.

  • Research Products

    (1 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Gefitinib enhances the efficacy of photodynamic therapy using 5-aminolevulinic acid in malignant brain tumor cells2013

    • Author(s)
      Wei Sun, Yoshinaga Kajimoto, Hiroto Inoue, Shin-Ichi Miyatake, Toshihisa Ishikawa, Toshihiko Kuroiwa
    • Journal Title

      Photodiagnosis and photodynamic therapy

      Volume: 10 Pages: 42-50

    • Peer Reviewed

URL: 

Published: 2015-07-16  

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