2013 Fiscal Year Final Research Report
Regulation of the chondroitin sulfate and recovery systems from the spinal cord injury.
| Project/Area Number |
23592161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Niigata University |
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Principal Investigator |
TAKEUCHI Kosei 新潟大学, 医歯(薬)学総合研究科, 客員研究員 (90206946)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脊髄損傷 / 再生医療 / グリコサミノグリカン |
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| Research Abstract |
Extracellular factors that inhibit axon growth and intrinsic factors that promote it affect neural regeneration. Therapies targeting any single gene have not yet simultaneously optimized both types of factors. Chondroitin sulphate (CS), a glycosaminoglycan, is the most abundant extracellular inhibitor of axon growth. Here we show that mice carrying a gene knockout for CS N-acetylgalactosaminyltransferase-1 (T1), a key enzyme in CS biosynthesis, recover morecompletely from spinal cord injury than wild-type mice and even chondroitinase ABC-treated mice.Taken together, our results indicate that regulation of a single gene, T1, mediates excellent recovery from spinal cord injury by optimizing counteracting effectorsof axon regeneration
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