2013 Fiscal Year Final Research Report

Effect of lipid cytokine on arthritis

Research Project

Project/Area Number	23592226
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Orthopaedic surgery
Research Institution	Osaka City University
Principal Investigator	KOIKE Tatsuya 大阪市立大学, 医学(系)研究科(研究院), 教授 (50271177)
Co-Investigator(Kenkyū-buntansha)	EBIHARA Ken 京都大学, 大学院医学研究科, 准教授 (70362514) TADA Masahiro 大阪市立大学, 大学院医学研究科, 病院講師 (20514235)
Project Period (FY)	2011 – 2013
Keywords	肥満 / 炎症 / レプチン / マウス
Research Abstract	Among rheumatoid arthritis patients, fatty patients show relatively low inflammation. So we thought that leptin derived from fat tissue might reduce the inflammation. At first ob/ob mouse, which has no leptin in the body, did not show any kind of arthritis induced by anti-collagen antibody. Next we created acquired leptin resistance mice by high fat diet. They got higher leptin concentration and showed lower grade of arthritis induced by anti-collagen antibody. At last, we could not induce arthritis in leptin transgenic mice, which showed hyperleptinemia. Finally we found that leptin decreased the production of IL-6, pro-inflammatory cytokine. Hyperleptinemia reduces inflammation.

(4 results)