2013 Fiscal Year Final Research Report
The role of ASICs in neuroprotection after spinal ischemia
| Project/Area Number |
23592305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagoya City University |
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Principal Investigator |
KUSAMA NOBUYOSHI 名古屋市立大学, 医学(系)研究科(研究院), 講師 (60336691)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIURA Takeshi 名古屋市立大学, 大学院医学研究科, 講師 (20295611)
SOBUE Kazuya 名古屋市立大学, 大学院医学研究科, 教授 (90264738)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ASIC |
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| Research Abstract |
Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. ASIC1a channels possess intersubunit Cl-binding sites in the extracellular domain, which are highly conserved between ASIC subunits. We found that anions modulate a variety of ASIC properties and are dependent on the subunit composition, and the mechanism of modulation for ASIC2a and ASIC3 is distinct from that of ASIC1a. We speculate that modulation of ASIC gating by Cl is a novel mechanism to sense shifts in extracellular fluid composition.
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