2013 Fiscal Year Final Research Report
Cancer stem cell model and nasopharyngeal carcinogenesis
| Project/Area Number |
23592522
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIZAKI Tomokazu 金沢大学, 医学系, 教授 (70262582)
WAKISAKA Naohiro 金沢大学, 大学病院, 講師 (70377414)
KONDO Satoru 金沢大学, 大学病院, 助教 (70436822)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 上咽頭癌 / EBウイルス / LMP1 / 癌幹細胞 |
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| Research Abstract |
Association of Epstein-Barr virus (EBV) with nasopharyngela carcinoma is know. However, mechanism of nasopharyngeal carcinogenesis is not clarified yet. In the present study, we showed that EBV latent membrane protein 1 (LMP1), a viral oncoprotein, induced a cellular morphorogical change as well as epithelial-mesenchymal transition through transcription factors including Twist and snail in nasopharyngeal epithelial cells. Furthermore, comparison of expression of ABCG2, Nanog, Nestin, Oct4, KLF4 and c-Myc between cells with and without LMP1 expression revealed that LMP1 induced cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines.
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