Analysis of retinal nerve fiber bundle damages in glaucoma by using adaptive optics laser scanning ophthalmoscope

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592565
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Saitama Medical University (2013); Kyoto University (2011-2012)
• Principal Investigator: HANGAI Masanori 埼玉医科大学, 医学部, 教授 (70283687)
• Co-Investigator(Kenkyū-buntansha): OOTO Sotaro 京都大学, 医学(系)研究科(研究院), 助教 (10511850) ; NONAKA Atsushi 京都大学, 医学(系)研究科(研究院), 助教 (40532601)
• Project Period (FY): 2011 – 2013
• Keywords: 緑内障 / 補償光学 / イメージング / 網膜神経線維束 / 神経節細胞

Research Abstract

We showed that adaptive optics scanning laser ophthalmoscope (AO-SLO) we originally developed enables clear visualization of the retinal nerve fiber bundles. Retinal nerve fiber bundles seen on AO-SLO revealed structural characteristics of retinal nerve fiber bundles in normal eyes. AL-SLO allowed reproducible measurement of retinal nerve fiber bundle width. Based on this normal findings, we demonstrated that retinal nerve fiber bundles are significantly narrower in glaucomatous eyes than in normal eyes. This abnormality in retinal nerve fiber bundles was associated with visual field sensitivity decrease in cluster. Our report of these findings are the first one as far as we are aware. Our study suggested that AO-SLO is able to analyze the retinal nerve fiber bundle width that no other technologies could not. Thus, retinal nerve fiber bundle imaging on AO-SLO may open a new avenue for glaucoma diagnosis based on 3-dimensional analysis of internal structure of retinal nerve fiber layer.

Research Products

• [Journal Article] High-resolution imaging of retinal nerve fiber bundles in glaucoma using adaptive optics scanning laser ophthalmoscopy (2013)
  • Author(s): Takayama K, Ooto S, Hangai M, Ueda-Arakawa N, Yoshida S, Akagi T, Ikeda HO, Nonaka A, Hanebuchi M, Inoue T, Yoshimura N
  • Journal Title: Am J Ophthalmol Volume: 155(5) Pages: 870-81
  • DOI: 10.1016/j.ajo.2012.11.016
  • Peer Reviewed
• [Journal Article] High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy (2012)
  • Author(s): Takayama K, Ooto S, Hangai M, Arakawa N, Oshima S, Shibata N, Hanebuchi M, Inoue T, Yoshimura N
  • Journal Title: PLoS One Volume: 7(3) Pages: e33158
  • DOI: 10.1371/journal.pone.0033158
  • Peer Reviewed
• [Presentation] Adaptive Optics SLOによる網膜神経線維束の可視化シンポジウム【最新緑内障検査機器のアップデート】 (2014)
  • Author(s): 大音壯太郞
  • Organizer: 日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 20140403-06
• [Presentation] Adaptive Optics in Glaucoma (2014)
  • Author(s): Sotaro Ooto
  • Organizer: World Ophthalmology Congress
  • Place of Presentation: 東京(Symposium)
  • Year and Date: 20140403-06
• [Presentation] Adaptive optics and optical coherence tomography (2014)
  • Author(s): Masanori Hangai
  • Organizer: World Ophthalmology Congress
  • Place of Presentation: 東京(Symposium)
  • Year and Date: 20140403-06
• [Presentation] 補償光学走査型レーザー検眼鏡を用いた緑内障眼における網膜神経線維束の高解像度イメージングシンポジウム (2013)
  • Author(s): 高山弘平、大音壮太郎、板谷正紀、赤木忠通、池田華子、吉村長久
  • Organizer: 日本緑内障学会
  • Place of Presentation: 東京
  • Year and Date: 20130921-23