2013 Fiscal Year Final Research Report
Molecular biological investigation for age-related macular degeneration and order made treatment
| Project/Area Number |
23592573
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University |
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Principal Investigator |
YUJI Oshima 九州大学, 大学病院, 助教 (00536237)
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| Co-Investigator(Kenkyū-buntansha) |
SONODA Koh-hei 山口大学医学部, 眼科, 教授 (10294943)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 眼生化学 / 分子生物学 |
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| Research Abstract |
Age Related Macular Degeneration (AMD) is the main cause of legal blindness in the Western and Asian countries. The pathogenesis is the choroidal neovascularization (CNV) beneath the macula in the retina. The anti-VEGF therapy is the major treatment, but there still many intractable cases. We investigated the effectiveness of cytokines for CNV progression, and the correlation of genetic background and treatment effect to search new treatment. IL-27 was significantly reduced CNV progression by VEGF secretion blocking. And the injection of IL-17 blockage in CNV model mouse eye significantly reduced CNV progression. These cytokines are supposed to be one of the new treatment targets for AMD. Although we also investigated the correlation between some SNPs and the effectiveness of anti-VEGF therapy from clinical data, there aren't significantly differences between them for early treatment phase.
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[Journal Article] IL-23-independent induction of IL-17 fromγδT cells and innate lymphoid cells promotes experimental intraocular neovascularization2013
Author(s)
Eiichi Hasegawa, Koh-hei Sonoda, Takashi Shichita, Rimpei Morita, Takashi Sekiya, Akihiro Kimura, Yuji Oshima, Atsunobu Takeda, Takeru Yoshimura, Shigeo Yoshida, Tatsuro Ishibashi, and Akihiko Yoshimura
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Journal Title
J Immunol
Volume: 190(4)
Pages: 1778-1787
DOI
Peer Reviewed
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