2013 Fiscal Year Final Research Report
Study of cerebral cortical mechanisms possibly responsible for jaw-movement disorders
| Project/Area Number |
23592699
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YOSHIDA Atsushi 大阪大学, 歯学研究科(研究院), 教授 (90201855)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takafumi 大阪大学, 大学院歯学研究科, 講師 (50367520)
ONO Takahiro 大阪大学, 大学院歯学研究科, 准教授 (30204241)
MORITANI Masayuki 森ノ宮医療大学, 保健医療学部, 教授 (80303981)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 顎運動 / 三叉神経運動核 / 運動ニューロン / 大脳皮質 |
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| Research Abstract |
Electrical stimulation of the primary somatosensory cortex and the lateral part of the prefrontal cortex (insular cortex) as well as the lateral part of the agranular cortex induced jaw-movements which are specific for the cortical location stimulated. However, stimulation of the medial part of the agranular cortex did not induce any jaw-movements. These cortical areas sent direct projections to the trigeminal sensory nuclear complex and the reticular formation around the trigeminal motor nucleus both of which include excitatory and/or inhibitory premotoneurons. Note that such premotoneurons were also found in the solitary tract nucleus.
These results may indicate that several indirect projections from the cerebral cortical areas to the trigeminal motor nucleus via its premotoneurons are involved in the induction of the characteristic jaw-movements, and the jaw-movement disorders are attributed to the disorders of the indirect projection systems from the cerebral cortical areas.
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[Journal Article] Jaw-opening and -closing premotoneurons in the nucleus of the solitary tract making contacts with laryngeal and pharyngeal afferent terminals in rats2013
Author(s)
Oka A, Yamamoto M, Takeda R, Ohara H, Sato F, Akhter F, Haque T, Kato T, Sessle BJ, Takada K, Yoshida A
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Journal Title
Brain Res
Volume: 1540
Pages: 48-63
DOI
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[Journal Article] Somatotopic direct projections from orofacial areas of primary somatosensory cortex to pons and medulla, especially to trigeminal sensory nuclear complex, in rats2012
Author(s)
A Tomita, T Kato, F Sato, T Haque, A Oka, M Yamamoto, T Ono, Y- C Bae, Y Maeda, BJ Sessle, A Yoshida
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Journal Title
Neuroscience
Volume: 200
Pages: 166-185
DOI
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[Presentation] DIRECT PROJECTIONS FROM THE PREFRONTAL CORTEX TO OROFACIAL PAIN-RELATED LOWER BRAINSTEM AREAS, ESPECIALLY TO THE TRIGEMINAL CAUDAL SUBNUCLEUS, IN RATS2013
Author(s)
A YOSHIDA, F SATO, F AKHTER, T HAQUE, T KATO, R TAKEDA, K HIGASHIYAMA, T FUJIO, H OHARA
Organizer
4th International Congress on Neuropathic Pain
Place of Presentation
Metro Toronto Convention Centre, Toronto, Canada
Year and Date
20130523-26
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[Presentation] Projections from the insular cortex to pain-receptive trigeminal caudal subnucleus (medullary dorsal horn) and other lower brainstem areas in rats2013
Author(s)
F Sato, T Hque, A Oka, K Higashiyama, K Yamada, F Akhter, H Ohara, T Fujio, M Yamamoto, K Uchino, T Kato, A Yoshida
Organizer
日本神経科学会Neuro2013
Place of Presentation
国立京都国際会館、京都市
Year and Date
2013-06-20
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[Presentation] Direct projections from the insular cortex to orofacial pain-related lower brainstem areas, especially to the trigeminal caudal subnucleus, in rats2012
Author(s)
F SATO, F AKHTER, T HAQUE, T KATO, R TAKEDA, K HIGASHIYAMA, Y-BAE, A YOSHIDA
Organizer
Society of Neuroscience Annual Meeting
Place of Presentation
New Orleans, USA Society of Neuroscience Annual Meeting
Year and Date
20121013-17
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[Presentation] Projections to the trigeminal jaw-opening and jaw-closing premotoneurons in the nucleus of the solitary tract from the pharyngeal mucosa and the insular cortex in rats2012
Author(s)
A OKA, R TAKEDA, F SATO, F AKHTER, TL HAQUE, T KATO, H OHARA, Y-C BAE, K TAKADA, A YOSHIDA
Organizer
The Ernest N. Morial Convention Center
Place of Presentation
New Orleans, USA Society of Neuroscience Annual Meeting
Year and Date
20121013-17
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