2013 Fiscal Year Final Research Report
Elucidation of metabolites from periodontopathogenic bacteria on their biofilm formation and virulence.
| Project/Area Number |
23592721
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
YOSHIDA Yasuo 愛知学院大学, 歯学部, 准教授 (10315096)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Fuminobu 愛知学院大学, 歯学部, 教授 (50001962)
NAGANO Keiji 愛知学院大学, 歯学部, 講師 (60367620)
HASEGAWA Yoshiaki 朝日大学, 歯学部, 講師 (70460524)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 代謝産物 / 歯周病 / バイオフィルム |
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| Research Abstract |
Metabolites, including indole, have an effect on bacterial biofilm formation. In this study, study on tryptophanase producing indole was performed. Tryptophanase of Prevotella intermedia, which is one of periodontopathogenic bacteria, was purified and enzymatically characterized. In addition, capacity to produce indole and existence of the gene encoding tryptophanase were examined in 22 Prevetella species. Also, proteins to degrade and produce cyclic-di-nucleotides also investigated.
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