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2013 Fiscal Year Final Research Report

Elucidation of the pathological mechanism on abnormal iron metabolism using a rat model

Research Project

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Project/Area Number 23592735
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

NOMA Takafumi  徳島大学, ヘルスバイオサイエンス研究部, 教授 (40189428)

Project Period (FY) 2011 – 2013
KeywordsSp6 / 歯原性上皮細胞 / 鉄代謝 / テトラサイクリン遺伝子誘導系 / 細胞内輸送
Research Abstract

Based on our finding that Sp6 functions in not only morphological differentiation but also iron metabolism during tooth development, I performed a study to clarify a role of iron metabolism in the developmental control of Sp6. The iron supply for the ameloblast was the same as normal control in Sp6 Tg rat, suggesting two possibilities of the release imperfection from lysosomal ferritin and iron complex in the cell, or the secretion imperfection from the ameloblasts. Then, to further analyze the relationship between Sp6 and lysosomal function or secreting mechanism, I tried to condtruct the tet induction system for Sp6 using the dental epithelial cells that were originally established in my laboratory. Unfortunately, I could not lead to establish the tet inducible system by this moment. In addition, I found the involvement of Sp6 in Rock1 gene regulation, which is related to secretion mechanism.

  • Research Products

    (11 results)

All 2014 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (7 results)

  • [Journal Article] Sp6 regulation of Rock1 promoter activity in dental epithelial cells2014

    • Author(s)
      Yanuaryska RD, Miyoshi K, Adiningrat A, Horiguchi T, Tanimura A, Hagita H, and Noma T.
    • Journal Title

      J Med Invest

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Ctip2-mediated Sp6 transcriptional regulation in dental epithelium-derived cells2014

    • Author(s)
      Adiningrat A, Tanimura A, Miyoshi K, Yanuaryska RD, Hagita H, Horiguchi T, and Noma T
    • Journal Title

      J Med Invest

      Volume: 61 Pages: 126-136

    • Peer Reviewed
  • [Journal Article] Novel genetic linkage of rat Sp6 mutation to Amelogenesis imperfect2012

    • Author(s)
      Muto T, Miyoshi K, Horiguchi T, Hagita H, Noma T
    • Journal Title

      Orphanet Journal of Rare Diseases

      Volume: 7 Pages: 1-11

    • DOI

      10.1186/1750-1172-7-34

    • Peer Reviewed
  • [Journal Article] Dissection of morphological and metabolic differentiation of ameloblasts via ectopic SP6 expression2012

    • Author(s)
      Muto T, Miyoshi K, Horiguchi T
    • Journal Title

      J Med Invest

      Volume: 59 Pages: 59-68

    • Peer Reviewed
  • [Presentation] Role of Ctip2 in Sp6 gene regulation2013

    • Author(s)
      Adiningrat A, Tanimura A, Miyoshi K, Yanuaryska RD, Horiguchi T, Hagita H, and Noma T
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2013-12-04
  • [Presentation] SP6 Positively Regulates Rock1 Promoter Activity in Dental Epithelial Cells2013

    • Author(s)
      Yanuaryska RD, Miyoshi K, Horiguchi T, Tanimura A, Adiningrat A, and Noma T
    • Organizer
      第55回歯科基礎医学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Year and Date
      2013-09-21
  • [Presentation] 転写因子SP6の構造と機能解析2013

    • Author(s)
      三好圭子, Yanuaryska RD, Adiningrat A,萩田浩子,谷村綾子,堀口大吾
    • Organizer
      第54回日本生化学会中国・四国支部例会
    • Place of Presentation
      徳島大学大塚講堂(徳島県)
    • Year and Date
      2013-06-01
  • [Presentation] SP6 and AP2 regulate Rock1 expression in dental epithelial cells2013

    • Author(s)
      Yanuaryska RD, Miyoshi K, Horiguchi T, Tanimura A, Hagita H, and Noma T
    • Organizer
      第54回日本生化学会中国・四国支部例会
    • Place of Presentation
      徳島大学大塚講堂(徳島県)
    • Year and Date
      2013-06-01
  • [Presentation] エナメル質形成不全症の新規遺伝子の発見2012

    • Author(s)
      三好圭子,武藤太郎,堀口大吾、萩田浩子、野間隆文
    • Organizer
      第57回日本人類遺伝学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2012-10-25
  • [Presentation] Identification of SP6 target genes in rat dental epithelial cell2011

    • Author(s)
      Yanuaryska RD, Miyoshi K, Utami TW, Horiguchi T, and Noma T
    • Organizer
      第53回歯科基礎医学会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Year and Date
      2011-10-01
  • [Presentation] SP6 stability and functional linkage during amelogenesis2011

    • Author(s)
      Utami TW, Miyoshi K, Hagita H, Yanuaryska RD, Horiguchi T, and Noma T
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-22

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Published: 2015-07-16  

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