2013 Fiscal Year Final Research Report
Elucidation of the pathological mechanism on abnormal iron metabolism using a rat model
| Project/Area Number |
23592735
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NOMA Takafumi 徳島大学, ヘルスバイオサイエンス研究部, 教授 (40189428)
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| Project Period (FY) |
2011 – 2013
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| Keywords | Sp6 / 歯原性上皮細胞 / 鉄代謝 / テトラサイクリン遺伝子誘導系 / 細胞内輸送 |
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| Research Abstract |
Based on our finding that Sp6 functions in not only morphological differentiation but also iron metabolism during tooth development, I performed a study to clarify a role of iron metabolism in the developmental control of Sp6. The iron supply for the ameloblast was the same as normal control in Sp6 Tg rat, suggesting two possibilities of the release imperfection from lysosomal ferritin and iron complex in the cell, or the secretion imperfection from the ameloblasts. Then, to further analyze the relationship between Sp6 and lysosomal function or secreting mechanism, I tried to condtruct the tet induction system for Sp6 using the dental epithelial cells that were originally established in my laboratory. Unfortunately, I could not lead to establish the tet inducible system by this moment. In addition, I found the involvement of Sp6 in Rock1 gene regulation, which is related to secretion mechanism.
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Research Products
(11 results)
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[Presentation] 転写因子SP6の構造と機能解析2013
Author(s)
三好圭子, Yanuaryska RD, Adiningrat A,萩田浩子,谷村綾子,堀口大吾
Organizer
第54回日本生化学会中国・四国支部例会
Place of Presentation
徳島大学大塚講堂(徳島県)
Year and Date
2013-06-01
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