2013 Fiscal Year Final Research Report
Mechanism of gingival overgrowth caused by medication - Expression and role of ets transcription factor -
| Project/Area Number |
23592779
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AKIMOTO Yoshiaki 日本大学, 松戸歯学部, 教授 (10147720)
ONO Makiko 日本大学, 松戸歯学部, 助手 (00267113)
TAKEUCHI Reiri 日本大学, 松戸歯学部, 助手 (60419778)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 歯肉肥厚 / 細胞増殖 / 細胞周期 / ets-1 / フェニトイン |
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| Research Abstract |
IL-1a increased phosphorylations of ERK, p38 MAPK, and HSP27, and expression of Ets-1 in human gingival fibroblasts. The inhibition of G1 cell cycle arrest in human gingival fibroblasts may result from an increase in phosphorylated Cdk2 and Rb proteins and decreased levels of p21 and p27 proteins by phenytoin. Because the phosphorylation of Ets-1 is controlled by cyclin, it is suggested that expressions of Ets-1 and ESE-3 by IL-1a is associated with gingival overgrowth.
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