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2013 Fiscal Year Final Research Report

The influence on bone marrow cells of the indoor environment chemicals: Analysis of dendritic cell differentiation and the Treg induction

Research Project

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Project/Area Number 23601027
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Children studies (Studies of environment on children)
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

SUGIURA Tsutomu  産業医科大学, 医学部, 非常勤講師 (40131924)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Yasuhiro  産業医科大学, 医学部, 准教授 (10309958)
KURODA Etsushi  産業医科大学, 医学部, 講師 (10299604)
Project Period (FY) 2011 – 2013
Keywords室内環境化学物質 / 制御性T細部 / 骨髄由来細胞 / STAT5
Research Abstract

As it has been reported that exposure of a wide variety of chemical substances to the child was increased, we investigated the effect of a substance chemical, such as formaldehyde and toluene, which is suspected in particular the effect of chemical prenatal period. From consideration of the exposure model mice, thymocytes immediately prepared from exposed mice after birth. Additionally, bone marrow derived cells were also highly activated.
Thus, the low concentration chemical prenatal exposure affected cellular events on the molecular level.

  • Research Products

    (5 results)

All 2013 2012 2011

All Journal Article (1 results) Presentation (4 results) (of which Invited: 4 results)

  • [Journal Article] Developmental stage-specific changes in immunological biomarkers in male C3H/HeN mice after early life toluene exposure2012

    • Author(s)
      Tin-Tin Win-Shwe, Naoki Kunugita, Daisuke Nakajima, Yasuhiro Yoshida, Hidekazu Fujimaki.
    • Journal Title

      Toxicology Letters

      Volume: 208 Pages: 133-141

    • DOI

      10.1016/j.toxlet.2011.10.015

  • [Presentation] 室内環境汚染物質2-エチルヘキサノールの免疫細胞機能に対する影響2013

    • Author(s)
      森田健太郎,吉田安宏ら
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Year and Date
      2013-12-04
    • Invited
  • [Presentation] The indoor air pollutant 2-ethyl-hexanol affects immune cells2012

    • Author(s)
      森田健太郎,吉田安宏ら.
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2012-10-20
    • Invited
  • [Presentation] 化学物質暴露による特異抗体の検出に関する研究2012

    • Author(s)
      余旭勝,吉田安宏ら.
    • Organizer
      第30回産業医科大学学会
    • Place of Presentation
      ラマツィーニホール(北九州)
    • Year and Date
      2012-10-20
    • Invited
  • [Presentation] Intratracheal administration of Asian sand dust induces autophagic and apoptotic phenomena in splenocytes2011

    • Author(s)
      Song, Y., Yoshida, Y.
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-08
    • Invited

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Published: 2015-07-16  

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