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2013 Fiscal Year Final Research Report

Fundamental and clinical studies on angiogenesis by vibration therapy: Why does the comfortable vibration promote wound healing?

Research Project

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Project/Area Number 23612001
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Mechanobiology
Research InstitutionThe University of Tokyo

Principal Investigator

NAGASE Takashi  東京大学, 医学(系)研究科(研究院), 客員研究員 (00359613)

Co-Investigator(Kenkyū-buntansha) NAKAGAMI Gojiro  東京大学, 大学院医学系研究科, 講師 (70547827)
MINEMATSU Takeo  東京大学, 大学院医学系研究科, 講師 (00398752)
MORI Taketoshi  東京大学, 大学院医学系研究科, 准教授 (20272586)
AKASE Tomoko  横浜市立大学, 医学部, 教授 (50276630)
Co-Investigator(Renkei-kenkyūsha) SANADA Hiromi  東京大学, 大学院医学系研究科, 教授 (50143920)
Project Period (FY) 2011 – 2013
Keywords創傷看護学
Research Abstract

Our research group have developed a novel wound healing vibrator. In this study, we investigated the effects and its molecular mechanisms of vibrator on the deep tissue injuries (DTIs) and diabetic foot ulcers, for which the effective intervention have not been established.
We investigated the effects of vibration on DTI in the animal study, in which we used a unique model rat for DTI deterioration. We revealed that vibration improved the tissue hypoxia and remarkably attenuated the ulceration of wounds.
We conducted a randomized control study in two hospitals in Indonesia (international collaborative research) to reveal the promoting effect of vibration on diabetic foot ulcer. We found the significant decreases of wound area reduction and healing period in the vibration group.

  • Research Products

    (7 results)

All 2014 2013 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Establishment of a Novel Rat Model for Deep Tissue Injury Deterioration2013

    • Author(s)
      Sari Y, Minematsu T, Huang L, Noguchi H, Mori T, Nakagami G, Nagase T, Oe M, Sugama J, Yoshimura K, Sanada H
    • Journal Title

      International Wound Journal

    • DOI

      10.1111/iwj.12082.[Epubaheadofprint]

    • Peer Reviewed
  • [Presentation] New insight in etiology of deep tissue injury2012

    • Author(s)
      Nagase T, Sanada H, Nakagami G, Minematsu T, Sari Y, Sugama J
    • Organizer
      4th Congress of the World Union of Wound Healing Societies
    • Place of Presentation
      Yokohama (Japan)
    • Year and Date
      20120902-06
  • [Presentation] Vibration attenuates the deterioration of deep tissue injury2012

    • Author(s)
      Sari Y, Minematsu T, Nakagami G, Nagase T, Oe M, Mori T, Sugama J, Sanada H
    • Organizer
      4th Congress of the World Union of Wound Healing Societies
    • Place of Presentation
      Yokohama (Japan)
    • Year and Date
      20120902-06
  • [Presentation] Activation of MMP-2 and MMP-9 during Deterioration of Deep Tissue Injury in Rats2011

    • Author(s)
      Sari Y, Minematsu T, Nakagami G, Akase T, Nagase T, Oe M, Mori T, Sugama J, Sanada H
    • Organizer
      第13回日本褥瘡学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      20110826-27
  • [Presentation] Vibration attenuates the deterioration of deep tissue injury2011

    • Author(s)
      Sari Y, Minematsu T, Nakagami G, Akase T, Nagase T, Oe M, Mori T, Sugama J, Sanada H
    • Organizer
      第13回日本褥瘡学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      20110826-27
  • [Presentation] Establishment of novel model for deterioration of deep tissue injury in rat2011

    • Author(s)
      Sari Y, Minematsu T, Nakagami G, Akase T, Nagase T, Oe M, Mori T, Sugama J, Sanada H
    • Organizer
      第20回日本創傷・オストミー・失禁管理学会学術集会
    • Place of Presentation
      石川
    • Year and Date
      20110521-22
  • [Book] Chapter 3, Nursing Biology. In, Bioengineering Nursing : New horizons of nursing research (Sanada H, Mori T & Nagase T, Eds)2014

    • Author(s)
      Minematsu T, Tamai N, Nishijima Y
    • Total Pages
      25-59
    • Publisher
      Nova Science Publisher

URL: 

Published: 2015-07-16  

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